Mar. Drugs 2010, 8(8), 2417-2434; doi:10.3390/md8082417
Review

Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs

Stephen A. Stricker* email, Jose R. Escalonaemail, Samuel Abernathyemail and Alicia Marquardtemail
Department of Biology, University of New Mexico, MSC03 2020, Albuquerque, NM 87131, USA
* Author to whom correspondence should be addressed.
Received: 21 June 2010; in revised form: 24 July 2010 / Accepted: 20 August 2010 / Published: 24 August 2010
(This article belongs to the Special Issue Structural and Functional Biology of Hypothetical Proteins in Marine Life)
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Abstract: For development to proceed normally, animal eggs must undergo a maturation process that ultimately depends on phosphorylations of key regulatory proteins. To analyze the kinases that mediate these phosphorylations, eggs of marine nemertean worms have been treated with pharmacological modulators of intracellular signaling pathways and subsequently probed with immunoblots employing phospho-specific antibodies. This article both reviews such analyses and compares them with those conducted on mammals, while focusing on how egg maturation in nemerteans is affected by signaling pathways involving cAMP, mitogen-activated protein kinases, Src-family kinases, protein kinase C isotypes, AMP-activated kinase, and the Cdc2 kinase of maturation-promoting factor.
Keywords: GVBD; AMPK; MPF

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Cite This Article

MDPI and ACS Style

Stricker, S.A.; Escalona, J.R.; Abernathy, S.; Marquardt, A. Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs. Mar. Drugs 2010, 8, 2417-2434.

AMA Style

Stricker SA, Escalona JR, Abernathy S, Marquardt A. Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs. Marine Drugs. 2010; 8(8):2417-2434.

Chicago/Turabian Style

Stricker, Stephen A.; Escalona, Jose R.; Abernathy, Samuel; Marquardt, Alicia. 2010. "Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs." Mar. Drugs 8, no. 8: 2417-2434.

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