Mar. Drugs 2010, 8(8), 2395-2416; doi:10.3390/md8082395
Review

New One-Pot Methodologies for the Modification or Synthesis of Alkaloid Scaffolds

Amir E. Wahba 1 email and Mark T. Hamann 1,2,3,* email
1 Department of Pharmacognosy, The School of Pharmacy, The University of Mississippi, University, MS 38677, USA 2 Department of Pharmacology, The School of Pharmacy, The University of Mississippi, University, MS 38677, USA 3 National Center for Natural Products Research, The School of Pharmacy, The University of Mississippi, University, MS 38677, USA
* Author to whom correspondence should be addressed.
Received: 26 July 2010; in revised form: 30 July 2010 / Accepted: 20 August 2010 / Published: 24 August 2010
(This article belongs to the Special Issue Alkaloid Analogs)
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Abstract: There are several avenues by which promising bioactive natural products can be produced in sufficient quantities to enable lead optimization and medicinal chemistry studies. The total synthesis of natural products is an important, but sometimes difficult, approach and requires the development of innovative synthetic methodologies to simplify the synthesis of complex molecules. Various classes of natural product alkaloids are both common and widely distributed in plants, bacteria, fungi, insects and marine organisms. This mini-review will discuss the scope, mechanistic insights and enantioselectivity aspects of selected examples of recently developed one-pot methods that have been published in 2009 for the synthesis of substituted piperidines, quinolizidines, pyrrolidines, hexahydropyrrolizines, octahydroindolizines and g-lactams. In addition, progress on the synthesis of b-carboline (manzamine) alkaloids will also be discussed.
Keywords: one-pot synthesis; cascade reactions; marine alkaloids; total synthesis; semisynthesis; organocatalysis

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Cite This Article

MDPI and ACS Style

Wahba, A.E.; Hamann, M.T. New One-Pot Methodologies for the Modification or Synthesis of Alkaloid Scaffolds. Mar. Drugs 2010, 8, 2395-2416.

AMA Style

Wahba AE, Hamann MT. New One-Pot Methodologies for the Modification or Synthesis of Alkaloid Scaffolds. Marine Drugs. 2010; 8(8):2395-2416.

Chicago/Turabian Style

Wahba, Amir E.; Hamann, Mark T. 2010. "New One-Pot Methodologies for the Modification or Synthesis of Alkaloid Scaffolds." Mar. Drugs 8, no. 8: 2395-2416.

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