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Multiple Beneficial Health Effects of Natural Alkylglycerols from Shark Liver Oil
Laboratoire de Pharmacologie Moléculaire, Université de Rennes 1, France
Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, and Université Européenne de Bretagne, France
* Author to whom correspondence should be addressed.
Received: 7 June 2010; in revised form: 7 July 2010 / Accepted: 14 July 2010 / Published: 19 July 2010
Abstract: Alkylglycerols (alkyl-Gro) are ether lipids abundant in the liver of some elasmobranch fish species such as ratfishes and some sharks. Shark liver oil from Centrophorus squamosus (SLO), or alkyl-Gro mix from this source, have several in vivo biological activities including stimulation of hematopoiesis and immunological defences, sperm quality improvement, or anti-tumor and anti-metastasis activities. Several mechanisms are suggested for these multiple activities, resulting from incorporation of alkyl-Gro into membrane phospholipids, and lipid signaling interactions. Natural alkyl-Gro mix from SLO contains several alkyl-Gro, varying by chain length and unsaturation. Six prominent constituents of natural alkyl-Gro mix, namely 12:0, 14:0, 16:0, 18:0, 16:1 n-7, and 18:1 n-9 alkyl-Gro, were synthesized and tested for anti-tumor and anti-metastatic activities on a model of grafted tumor in mice (3LL cells). 16:1 and 18:1 alkyl-Gro showed strong activity in reducing lung metastasis number, while saturated alkyl-Gro had weaker (16:0) or no (12:0, 14:0, 18:0) effect. Multiple compounds and mechanisms are probably involved in the multiple activities of natural alkyl-Gro.
Keywords: alkylglycerols; shark liver oil; ether lipids; immunostimulation; anti-tumor activities
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Deniau, A.-L.; Mosset, P.; Pédrono, F.; Mitre, R.; Bot, D.L.; Legrand, A.B. Multiple Beneficial Health Effects of Natural Alkylglycerols from Shark Liver Oil. Mar. Drugs 2010, 8, 2175-2184.
Deniau A-L, Mosset P, Pédrono F, Mitre R, Bot DL, Legrand AB. Multiple Beneficial Health Effects of Natural Alkylglycerols from Shark Liver Oil. Marine Drugs. 2010; 8(7):2175-2184.
Deniau, Anne-Laure; Mosset, Paul; Pédrono, Frédérique; Mitre, Romain; Bot, Damien Le; Legrand, Alain B. 2010. "Multiple Beneficial Health Effects of Natural Alkylglycerols from Shark Liver Oil." Mar. Drugs 8, no. 7: 2175-2184.