Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity
AbstractMeroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.
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Simon-Levert, A.; Menniti, C.; Soulère, L.; Genevière, A.-M.; Barthomeuf, C.; Banaigs, B.; Witczak, A. Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity. Mar. Drugs 2010, 8, 347-358.
Simon-Levert A, Menniti C, Soulère L, Genevière A-M, Barthomeuf C, Banaigs B, Witczak A. Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity. Marine Drugs. 2010; 8(2):347-358.Chicago/Turabian Style
Simon-Levert, Annabel; Menniti, Christophe; Soulère, Laurent; Genevière, Anne-Marie; Barthomeuf, Chantal; Banaigs, Bernard; Witczak, Anne. 2010. "Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity." Mar. Drugs 8, no. 2: 347-358.