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Mar. Drugs 2010, 8(2), 347-358; doi:10.3390/md8020347

Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity

Laboratoire de Chimie des Biomolécules et de l’Environnement EA4215, Université de Perpignan via Domitia, 52 avenue Paul Alduy, 66860 Perpignan Cedex, France
INSA Lyon, Laboratoire de Chimie Organique, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Université de Lyon 1, UMR 5246, Bât J. Verne, 20 av A. Einstein, 69621 Villeurbanne Cedex, France
Observatoire Océanologique de Banyuls Laboratoire Arago, CNRS-UMR7628/IPMC, 66650 Banyuls-sur-Mer, France
Laboratoire de Pharmacognosie et Biotechnologies, Université d’Auvergne, 63001 Clermont-Ferrand, France
Author to whom correspondence should be addressed.
Received: 26 January 2010 / Accepted: 20 February 2010 / Published: 23 February 2010
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Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.
Keywords: meroterpene; methoxyconidiol; epiconicol; didehydroconicol; antiproliferative activity meroterpene; methoxyconidiol; epiconicol; didehydroconicol; antiproliferative activity

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Simon-Levert, A.; Menniti, C.; Soulère, L.; Genevière, A.-M.; Barthomeuf, C.; Banaigs, B.; Witczak, A. Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity. Mar. Drugs 2010, 8, 347-358.

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