Next Article in Journal
New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals
Previous Article in Journal
Bioactive Sesterterpenes and Triterpenes from Marine Sponges: Occurrence and Pharmacological Significance
Mar. Drugs 2010, 8(2), 347-358; doi:10.3390/md8020347
Article

Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity

1
, 1
, 2
, 3
, 4
, 1,*  and 1
1 Laboratoire de Chimie des Biomolécules et de l’Environnement EA4215, Université de Perpignan via Domitia, 52 avenue Paul Alduy, 66860 Perpignan Cedex, France 2 INSA Lyon, Laboratoire de Chimie Organique, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Université de Lyon 1, UMR 5246, Bât J. Verne, 20 av A. Einstein, 69621 Villeurbanne Cedex, France 3 Observatoire Océanologique de Banyuls Laboratoire Arago, CNRS-UMR7628/IPMC, 66650 Banyuls-sur-Mer, France 4 Laboratoire de Pharmacognosie et Biotechnologies, Université d’Auvergne, 63001 Clermont-Ferrand, France
* Author to whom correspondence should be addressed.
Received: 26 January 2010 / Accepted: 20 February 2010 / Published: 23 February 2010
View Full-Text   |   Download PDF [158 KB, uploaded 24 February 2015]   |   Browse Figures

Abstract

Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.
Keywords: meroterpene; methoxyconidiol; epiconicol; didehydroconicol; antiproliferative activity meroterpene; methoxyconidiol; epiconicol; didehydroconicol; antiproliferative activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Simon-Levert, A.; Menniti, C.; Soulère, L.; Genevière, A.-M.; Barthomeuf, C.; Banaigs, B.; Witczak, A. Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity. Mar. Drugs 2010, 8, 347-358.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert