Mar. Drugs 2010, 8(2), 347-358; doi:10.3390/md8020347

Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity

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Received: 26 January 2010; Accepted: 20 February 2010 / Published: 23 February 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.
Keywords: meroterpene; methoxyconidiol; epiconicol; didehydroconicol; antiproliferative activity
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MDPI and ACS Style

Simon-Levert, A.; Menniti, C.; Soulère, L.; Genevière, A.-M.; Barthomeuf, C.; Banaigs, B.; Witczak, A. Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity. Mar. Drugs 2010, 8, 347-358.

AMA Style

Simon-Levert A, Menniti C, Soulère L, Genevière A-M, Barthomeuf C, Banaigs B, Witczak A. Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity. Marine Drugs. 2010; 8(2):347-358.

Chicago/Turabian Style

Simon-Levert, Annabel; Menniti, Christophe; Soulère, Laurent; Genevière, Anne-Marie; Barthomeuf, Chantal; Banaigs, Bernard; Witczak, Anne. 2010. "Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity." Mar. Drugs 8, no. 2: 347-358.

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