Mar. Drugs 2010, 8(12), 2976-2987; doi:10.3390/md8122976

Biological Activity of Volatiles from Marine and Terrestrial Bacteria

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Received: 12 November 2010; in revised form: 7 December 2010 / Accepted: 17 December 2010 / Published: 22 December 2010
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Abstract: The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter strains. While some of the compounds specific to certain bacteria showed some activity in the antiproliferative assay, the compounds common to many bacteria were mostly inactive. In contrast, some of these compounds were active in the quorum-sensing-tests. γ-Lactones showed a broad reactivity, while pyrazines seem to have only low intrinsic activity. A general discussion on the ecological importance of these findings is given.
Keywords: lactones; sulfur compounds; pyrazines; bacterial communication; quorum-sensing; ketones; aromatic compounds; agar diffusion assay; terpenes
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MDPI and ACS Style

Schulz, S.; Dickschat, J.S.; Kunze, B.; Wagner-Dobler, I.; Diestel, R.; Sasse, F. Biological Activity of Volatiles from Marine and Terrestrial Bacteria. Mar. Drugs 2010, 8, 2976-2987.

AMA Style

Schulz S, Dickschat JS, Kunze B, Wagner-Dobler I, Diestel R, Sasse F. Biological Activity of Volatiles from Marine and Terrestrial Bacteria. Marine Drugs. 2010; 8(12):2976-2987.

Chicago/Turabian Style

Schulz, Stefan; Dickschat, Jeroen S.; Kunze, Brigitte; Wagner-Dobler, Irene; Diestel, Randi; Sasse, Florenz. 2010. "Biological Activity of Volatiles from Marine and Terrestrial Bacteria." Mar. Drugs 8, no. 12: 2976-2987.

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