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Special Issue "Marine Actinomycetes: A New Source of Natural Products"

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A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 December 2009)

Special Issue Editor

Guest Editor
Prof. Dr. Jose A. Salas

Department of Functional Biology (Area Microbiology), Faculty of Medicine, University of Oviedo, 33006 Oviedo, Spain
Website | E-Mail
Phone: +34 985 103652
Fax: +34 985 103652
Interests: bioactive natural products; anticancer agents; antimicrobial agents; biosynthesis

Special Issue Information

Dear Colleagues,

Actinomycetes are filamentous Gram-positive bacteria with a complex life cycle which are widely distributed in terrestrial ecosystems, especially in soil. They are producers of a large number of natural products, many of them with clinical, pharmaceutical or agricultural application. In the last decades, marine actinomycetes are increasingly being isolated from marine environments demonstrating that actinomycetes are ubiquitous in marine sediments, but at lower numbers than in soils. Furthermore, marine actinomycetes have been found in symbiosis with different marine invertebrates, especially sponges. They have attracted great attention since they have developed unique metabolic and physiological capabilities that offer the potential to produce natural products with interesting pharmacological activities and therefore they provide a source of novel natural products with potential application in the near future.

Prof. Dr. Jose A. Salas
Guest Editor

Keywords

  • non-ribosomal peptides
  • polyketides
  • Streptomyces
  • Micromonospora
  • secondary metabolites
  • bioactive compounds

Published Papers (2 papers)

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Research

Open AccessArticle Isolation, Phylogenetic Analysis and Anti-infective Activity Screening of Marine Sponge-Associated Actinomycetes
Mar. Drugs 2010, 8(3), 399-412; doi:10.3390/md8030399
Received: 29 December 2009 / Revised: 3 February 2010 / Accepted: 5 February 2010 / Published: 26 February 2010
Cited by 63 | PDF Full-text (273 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Terrestrial actinomycetes are noteworthy producers of a multitude of antibiotics, however the marine representatives are much less studied in this regard. In this study, 90 actinomycetes were isolated from 11 different species of marine sponges that had been collected from offshore Ras Mohamed
[...] Read more.
Terrestrial actinomycetes are noteworthy producers of a multitude of antibiotics, however the marine representatives are much less studied in this regard. In this study, 90 actinomycetes were isolated from 11 different species of marine sponges that had been collected from offshore Ras Mohamed (Egypt) and from Rovinj (Croatia). Phylogenetic characterization of the isolates based on 16S rRNA gene sequencing supported their assignment to 18 different actinomycete genera representing seven different suborders. Fourteen putatively novel species were identified based on sequence similarity values below 98.2% to other strains in the NCBI database. A putative new genus related to Rubrobacter was isolated on M1 agar that had been amended with sponge extract, thus highlighting the need for innovative cultivation protocols. Testing for anti-infective activities was performed against clinically relevant, Gram-positive (Enterococcus faecalis, Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria, fungi (Candida albicans) and human parasites (Leishmania major, Trypanosoma brucei). Bioactivities against these pathogens were documented for 10 actinomycete isolates. These results show a high diversity of actinomycetes associated with marine sponges as well as highlight their potential to produce anti-infective agents. Full article
(This article belongs to the Special Issue Marine Actinomycetes: A New Source of Natural Products)
Open AccessCommunication Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms
Mar. Drugs 2009, 7(4), 483-494; doi:10.3390/md7040483
Received: 26 August 2009 / Revised: 14 October 2009 / Accepted: 19 October 2009 / Published: 19 October 2009
Cited by 5 | PDF Full-text (289 KB) | HTML Full-text | XML Full-text
Abstract
Renieramycin M and jorunnamycin C, two isoquinolinequinone compounds differing only at the C-22 ester side chain, were evaluated for their cytotoxic effects on human colon (HCT116) and breast (MDA-MB-435) cancer cell lines. These two compounds displayed potent cancer cell growth inhibition, their IC
[...] Read more.
Renieramycin M and jorunnamycin C, two isoquinolinequinone compounds differing only at the C-22 ester side chain, were evaluated for their cytotoxic effects on human colon (HCT116) and breast (MDA-MB-435) cancer cell lines. These two compounds displayed potent cancer cell growth inhibition, their IC50 values reaching nanomolar order. To examine their effects on transcription, we carried out oligonucleotide microarray analysis with focus on the similarities and differences between the two compounds in terms of transcriptional profiles. We found that the down-regulation of PTPRK (protein tyrosine phosphatase receptor type K) can be considered as a biomarker responsive to the cytotoxic effects of this class of antitumor marine natural products. Full article
(This article belongs to the Special Issue Marine Actinomycetes: A New Source of Natural Products)
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