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Matrix Metalloproteinase Inhibitors (MMPIs) from Marine Natural Products: the Current Situation and Future Prospects
Mar. Drugs 2009, 7(2), 85-94; doi:10.3390/md7020085
Article

Fibrinolytic Compounds Isolated from a Brown Alga, Sargassum fulvellum

1, 2
,
3
,
4
,
1
 and
1,*
1 Department of Marine Biopharmacology, Shanghai Ocean University, Shanghai 201306, P. R. China 2 Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo 1838509, Japan 3 Department of Chemistry, The University of Auckland,Auckland 1142, New Zealand 4 Institute of Biotechnology, Beijing 100071, P. R. China
* Author to whom correspondence should be addressed.
Received: 13 February 2009 / Accepted: 4 April 2009 / Published: 7 April 2009
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Abstract

Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl) –glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl) – glycerol (MOGG) which were obtained from Sargassum fulvellum for the first time. POGG and MOGG showed fibrinolytic activity in the reaction system of pro-u-PA and plasminogen.
Keywords: fibrinolytic activity; NMR; glucopyranosyldiacylglycerol; structure determination; Sargassum fulvellum fibrinolytic activity; NMR; glucopyranosyldiacylglycerol; structure determination; Sargassum fulvellum
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wu, W.; Hasumi, K.; Peng, H.; Hu, X.; Wang, X.; Bao, B. Fibrinolytic Compounds Isolated from a Brown Alga, Sargassum fulvellum. Mar. Drugs 2009, 7, 85-94.

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