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Matrix Metalloproteinase Inhibitors (MMPIs) from Marine Natural Products: the Current Situation and Future Prospects
Mar. Drugs 2009, 7(2), 85-94; doi:10.3390/md7020085
Article

Fibrinolytic Compounds Isolated from a Brown Alga, Sargassum fulvellum

1, 2
, 3
, 4
, 1
 and 1,*
1 Department of Marine Biopharmacology, Shanghai Ocean University, Shanghai 201306, P. R. China 2 Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo 1838509, Japan 3 Department of Chemistry, The University of Auckland,Auckland 1142, New Zealand 4 Institute of Biotechnology, Beijing 100071, P. R. China
* Author to whom correspondence should be addressed.
Received: 13 February 2009 / Accepted: 4 April 2009 / Published: 7 April 2009
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Abstract

Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl) –glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl) – glycerol (MOGG) which were obtained from Sargassum fulvellum for the first time. POGG and MOGG showed fibrinolytic activity in the reaction system of pro-u-PA and plasminogen.
Keywords: fibrinolytic activity; NMR; glucopyranosyldiacylglycerol; structure determination; Sargassum fulvellum fibrinolytic activity; NMR; glucopyranosyldiacylglycerol; structure determination; Sargassum fulvellum
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wu, W.; Hasumi, K.; Peng, H.; Hu, X.; Wang, X.; Bao, B. Fibrinolytic Compounds Isolated from a Brown Alga, Sargassum fulvellum. Mar. Drugs 2009, 7, 85-94.

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