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Fibrinolytic Compounds Isolated from a Brown Alga, Sargassum fulvellum
Department of Marine Biopharmacology, Shanghai Ocean University, Shanghai 201306, P. R. China
Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo 1838509, Japan
Department of Chemistry, The University of Auckland，Auckland 1142, New Zealand
Institute of Biotechnology, Beijing 100071, P. R. China
* Author to whom correspondence should be addressed.
Received: 13 February 2009; Accepted: 4 April 2009 / Published: 7 April 2009
Abstract: Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl) –glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl) – glycerol (MOGG) which were obtained from Sargassum fulvellum for the first time. POGG and MOGG showed fibrinolytic activity in the reaction system of pro-u-PA and plasminogen.
Keywords: fibrinolytic activity; NMR; glucopyranosyldiacylglycerol; structure determination; Sargassum fulvellum
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MDPI and ACS Style
Wu, W.; Hasumi, K.; Peng, H.; Hu, X.; Wang, X.; Bao, B. Fibrinolytic Compounds Isolated from a Brown Alga, Sargassum fulvellum. Mar. Drugs 2009, 7, 85-94.
Wu W, Hasumi K, Peng H, Hu X, Wang X, Bao B. Fibrinolytic Compounds Isolated from a Brown Alga, Sargassum fulvellum. Marine Drugs. 2009; 7(2):85-94.
Wu, Wenhui; Hasumi, Keiji; Peng, Hui; Hu, Xianwen; Wang, Xichang; Bao, Bin. 2009. "Fibrinolytic Compounds Isolated from a Brown Alga, Sargassum fulvellum." Mar. Drugs 7, no. 2: 85-94.