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Mar. Drugs 2009, 7(2), 71-84; doi:10.3390/md7020071

Matrix Metalloproteinase Inhibitors (MMPIs) from Marine Natural Products: the Current Situation and Future Prospects

1
Department of Chemistry, Pukyong National University, Busan, 608-737, Republic of Korea
2
Marine Bioprocess Research Center, Pukyong National University, Busan, 608-737, Republic of Korea
*
Author to whom correspondence should be addressed.
Received: 22 December 2008 / Revised: 25 March 2009 / Accepted: 25 March 2009 / Published: 31 March 2009
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Abstract

Matrix metalloproteinases (MMPs) are a family of more than twenty five secreted and membrane-bound zinc-endopeptidases which can degrade extracellular matrix (ECM) components. They also play important roles in a variety of biological and pathological processes. Matrix metalloproteinase inhibitors (MMPIs) have been identified as potential therapeutic candidates for metastasis, arthritis, chronic inflammation and wrinkle formation. Up to present, more than 20,000 new compounds have been isolated from marine organisms, where considerable numbers of these naturally occurring derivatives are developed as potential candidates for pharmaceutical application. Eventhough the quantity of marine derived MMPIs is less when compare with the MMPIs derived from terrestrial materials, huge potential for bioactivity of these marine derived MMPIs has lead to large number of researches. Saccharoids, flavonoids and polyphones, fatty acids are the most important groups of MMPIs derived from marine natural products. In this review we focus on the progress of MMPIs from marine natural products. View Full-Text
Keywords: Matrix metalloproteinases (MMPs); Matrix metalloproteinase inhibitors (MMPIs); Tissue inhibitors of metalloproteinase (TIMPs); Marine natural products; NF-κB; AP-1. Matrix metalloproteinases (MMPs); Matrix metalloproteinase inhibitors (MMPIs); Tissue inhibitors of metalloproteinase (TIMPs); Marine natural products; NF-κB; AP-1.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, C.; Kim, S.-K. Matrix Metalloproteinase Inhibitors (MMPIs) from Marine Natural Products: the Current Situation and Future Prospects. Mar. Drugs 2009, 7, 71-84.

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