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Mar. Drugs 2009, 7(2), 210-248; doi:10.3390/md7020210
Review

Antitumor Compounds from Marine Actinomycetes

,
 and *
Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain
* Author to whom correspondence should be addressed.
Received: 25 May 2009 / Revised: 8 June 2009 / Accepted: 11 June 2009 / Published: 11 June 2009
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Abstract

Chemotherapy is one of the main treatments used to combat cancer. A great number of antitumor compounds are natural products or their derivatives, mainly produced by microorganisms. In particular, actinomycetes are the producers of a large number of natural products with different biological activities, including antitumor properties. These antitumor compounds belong to several structural classes such as anthracyclines, enediynes, indolocarbazoles, isoprenoides, macrolides, non-ribosomal peptides and others, and they exert antitumor activity by inducing apoptosis through DNA cleavage mediated by topoisomerase I or II inhibition, mitochondria permeabilization, inhibition of key enzymes involved in signal transduction like proteases, or cellular metabolism and in some cases by inhibiting tumor-induced angiogenesis. Marine organisms have attracted special attention in the last years for their ability to produce interesting pharmacological lead compounds.
Keywords: anthracycline; indolocarbazole; macrolide; non-ribosomal peptide synthetase; polyketide synthase anthracycline; indolocarbazole; macrolide; non-ribosomal peptide synthetase; polyketide synthase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Olano, C.; Méndez, C.; Salas, J.A. Antitumor Compounds from Marine Actinomycetes. Mar. Drugs 2009, 7, 210-248.

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