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Antitumor Compounds from Marine Actinomycetes
Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain
* Author to whom correspondence should be addressed.
Received: 25 May 2009; in revised form: 8 June 2009 / Accepted: 11 June 2009 / Published: 11 June 2009
Abstract: Chemotherapy is one of the main treatments used to combat cancer. A great number of antitumor compounds are natural products or their derivatives, mainly produced by microorganisms. In particular, actinomycetes are the producers of a large number of natural products with different biological activities, including antitumor properties. These antitumor compounds belong to several structural classes such as anthracyclines, enediynes, indolocarbazoles, isoprenoides, macrolides, non-ribosomal peptides and others, and they exert antitumor activity by inducing apoptosis through DNA cleavage mediated by topoisomerase I or II inhibition, mitochondria permeabilization, inhibition of key enzymes involved in signal transduction like proteases, or cellular metabolism and in some cases by inhibiting tumor-induced angiogenesis. Marine organisms have attracted special attention in the last years for their ability to produce interesting pharmacological lead compounds.
Keywords: anthracycline; indolocarbazole; macrolide; non-ribosomal peptide synthetase; polyketide synthase
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MDPI and ACS Style
Olano, C.; Méndez, C.; Salas, J.A. Antitumor Compounds from Marine Actinomycetes. Mar. Drugs 2009, 7, 210-248.
Olano C, Méndez C, Salas JA. Antitumor Compounds from Marine Actinomycetes. Marine Drugs. 2009; 7(2):210-248.
Olano, Carlos; Méndez, Carmen; Salas, José A. 2009. "Antitumor Compounds from Marine Actinomycetes." Mar. Drugs 7, no. 2: 210-248.