Cytotoxic Aaptamines from Malaysian Aaptos aaptos
AbstractIn a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.
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Shaari, K.; Ling, K.C.; Mat Rashid, Z.; Jean, T.P.; Abas, F.; Raof, S.M.; Zainal, Z.; Lajis, N.H.; Mohamad, H.; Ali, A.M. Cytotoxic Aaptamines from Malaysian Aaptos aaptos. Mar. Drugs 2009, 7, 1-8.
Shaari K, Ling KC, Mat Rashid Z, Jean TP, Abas F, Raof SM, Zainal Z, Lajis NH, Mohamad H, Ali AM. Cytotoxic Aaptamines from Malaysian Aaptos aaptos. Marine Drugs. 2009; 7(1):1-8.Chicago/Turabian Style
Shaari, Khozirah; Ling, Kee Cheng; Mat Rashid, Zalilawati; Jean, Tan Pei; Abas, Faridah; Raof, Salahudin Mohd.; Zainal, Zurina; Lajis, Nordin Hj.; Mohamad, Habsah; Ali, Abdul Manaf. 2009. "Cytotoxic Aaptamines from Malaysian Aaptos aaptos." Mar. Drugs 7, no. 1: 1-8.