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Mar. Drugs 2009, 7(1), 1-8; doi:10.3390/md7010001

Cytotoxic Aaptamines from Malaysian Aaptos aaptos

1,* , 1, 2, 1, 1, 1, 1, 1, 2 and 3
1 Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia 2 Department of Chemical Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia 3 Faculty of Biotechnology, Universiti Darul Iman, Kuala Terengganu, Terengganu, Malaysia
* Author to whom correspondence should be addressed.
Received: 10 November 2008 / Revised: 12 December 2008 / Accepted: 12 December 2008 / Published: 28 December 2008
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In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.
Keywords: Marine sponge; Aaptos aaptos; aaptaminoids; alkaloids; cytotoxicity Marine sponge; Aaptos aaptos; aaptaminoids; alkaloids; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shaari, K.; Ling, K.C.; Mat Rashid, Z.; Jean, T.P.; Abas, F.; Raof, S.M.; Zainal, Z.; Lajis, N.H.; Mohamad, H.; Ali, A.M. Cytotoxic Aaptamines from Malaysian Aaptos aaptos. Mar. Drugs 2009, 7, 1-8.

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