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Mar. Drugs 2009, 7(1), 1-8; doi:10.3390/md7010001
Article

Cytotoxic Aaptamines from Malaysian Aaptos aaptos

1,* , 1, 2, 1, 1, 1, 1, 1, 2 and 3
Received: 10 November 2008 / Revised: 12 December 2008 / Accepted: 12 December 2008 / Published: 28 December 2008
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Abstract

In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.
Keywords: Marine sponge; Aaptos aaptos; aaptaminoids; alkaloids; cytotoxicity Marine sponge; Aaptos aaptos; aaptaminoids; alkaloids; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shaari, K.; Ling, K.C.; Mat Rashid, Z.; Jean, T.P.; Abas, F.; Raof, S.M.; Zainal, Z.; Lajis, N.H.; Mohamad, H.; Ali, A.M. Cytotoxic Aaptamines from Malaysian Aaptos aaptos. Mar. Drugs 2009, 7, 1-8.

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