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Mar. Drugs 2008, 6(1), 12-24; doi:10.3390/md6010012
Article

Actinomycetes from Sediments in the Trondheim Fjord, Norway: Diversity and Biological Activity

1, 2, 3 and 2,*
Received: 21 November 2007; in revised form: 17 January 2008 / Accepted: 17 January 2008 / Published: 1 February 2008
(This article belongs to the Special Issue Bioactive Compounds from Marine Microorganisms)
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Abstract: The marine environment represents a largely untapped source for isolation of new microorganisms with potential to produce biologically active secondary metabolites. Among such microorganisms, Gram-positive actinomycete bacteria are of special interest, since they are known to produce chemically diverse compounds with a wide range of biological activities. We have set out to isolate and characterize actinomycete bacteria from the sediments in one of the largest Norwegian fjords, the Trondheim fjord, with respect to diversity and antibiotic-producing potential. Approximately 3,200 actinomycete bacteria were isolated using four different agar media from the sediment samples collected at different locations and depths (4.5 to 450 m). Grouping of the isolates first according to the morphology followed by characterization of isolates chosen as group representatives by molecular taxonomy revealed that Micromonospora was the dominating actinomycete genus isolated from the sediments. The deep water sediments contained a higher relative amount of Micromonospora compared to the shallow water samples. Nine percent of the isolates clearly required sea water for normal growth, suggesting that these strains represent obligate marine organisms. Extensive screening of the extracts from all collected isolates for antibacterial and antifungal activities revealed strong antibiotic-producing potential among them. The latter implies that actinomycetes from marine sediments in Norwegian fjords can be potential sources for the discovery of novel anti-infective agents.
Keywords: Actinomycete bacteria; fjord sediments; molecular taxonomy; antimicrobial activities Actinomycete bacteria; fjord sediments; molecular taxonomy; antimicrobial activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bredholt, H.; Fjærvik, E.; Johnsen, G.; Zotchev, S.B. Actinomycetes from Sediments in the Trondheim Fjord, Norway: Diversity and Biological Activity. Mar. Drugs 2008, 6, 12-24.

AMA Style

Bredholt H, Fjærvik E, Johnsen G, Zotchev SB. Actinomycetes from Sediments in the Trondheim Fjord, Norway: Diversity and Biological Activity. Marine Drugs. 2008; 6(1):12-24.

Chicago/Turabian Style

Bredholt, Harald; Fjærvik, Espen; Johnsen, Geir; Zotchev, Sergey B. 2008. "Actinomycetes from Sediments in the Trondheim Fjord, Norway: Diversity and Biological Activity." Mar. Drugs 6, no. 1: 12-24.



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