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Actinomycetes from Sediments in the Trondheim Fjord, Norway: Diversity and Biological Activity
Alpharma AS, Harbitzalleen 3, 0212 Oslo, Norway
Department of Biotechnology, Norwegian University of Science and Technology, 7491 Trondheim, Norway
Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway
* Author to whom correspondence should be addressed.
Received: 21 November 2007; in revised form: 17 January 2008 / Accepted: 17 January 2008 / Published: 1 February 2008
Abstract: The marine environment represents a largely untapped source for isolation of new microorganisms with potential to produce biologically active secondary metabolites. Among such microorganisms, Gram-positive actinomycete bacteria are of special interest, since they are known to produce chemically diverse compounds with a wide range of biological activities. We have set out to isolate and characterize actinomycete bacteria from the sediments in one of the largest Norwegian fjords, the Trondheim fjord, with respect to diversity and antibiotic-producing potential. Approximately 3,200 actinomycete bacteria were isolated using four different agar media from the sediment samples collected at different locations and depths (4.5 to 450 m). Grouping of the isolates first according to the morphology followed by characterization of isolates chosen as group representatives by molecular taxonomy revealed that Micromonospora was the dominating actinomycete genus isolated from the sediments. The deep water sediments contained a higher relative amount of Micromonospora compared to the shallow water samples. Nine percent of the isolates clearly required sea water for normal growth, suggesting that these strains represent obligate marine organisms. Extensive screening of the extracts from all collected isolates for antibacterial and antifungal activities revealed strong antibiotic-producing potential among them. The latter implies that actinomycetes from marine sediments in Norwegian fjords can be potential sources for the discovery of novel anti-infective agents.
Keywords: Actinomycete bacteria; fjord sediments; molecular taxonomy; antimicrobial activities
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Bredholt, H.; Fjærvik, E.; Johnsen, G.; Zotchev, S.B. Actinomycetes from Sediments in the Trondheim Fjord, Norway: Diversity and Biological Activity. Mar. Drugs 2008, 6, 12-24.
Bredholt H, Fjærvik E, Johnsen G, Zotchev SB. Actinomycetes from Sediments in the Trondheim Fjord, Norway: Diversity and Biological Activity. Marine Drugs. 2008; 6(1):12-24.
Bredholt, Harald; Fjærvik, Espen; Johnsen, Geir; Zotchev, Sergey B. 2008. "Actinomycetes from Sediments in the Trondheim Fjord, Norway: Diversity and Biological Activity." Mar. Drugs 6, no. 1: 12-24.