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Mar. Drugs 2007, 5(2), 40-51; doi:10.3390/md502040
Article

Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand

1, 2, 4, 4, 4, 5, 7 and 3,*
Received: 31 May 2007; Accepted: 23 June 2007 / Published: 25 June 2007
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Abstract: A new compound maleimide-5-oxime was isolated, together with 3,4- dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(-) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi.
Keywords: Haliclona baeri; Haliclona cymaeformis; tetillapyrone; nortetillapyrone; antifungal activity; dermatophytes Haliclona baeri; Haliclona cymaeformis; tetillapyrone; nortetillapyrone; antifungal activity; dermatophytes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wattanadilok, R.; Sawangwong, P.; Rodrigues, C.; Cidade, H.; Pinto, M.; Pinto, E.; Silva, A.; Kijjoa, A. Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand. Mar. Drugs 2007, 5, 40-51.

AMA Style

Wattanadilok R, Sawangwong P, Rodrigues C, Cidade H, Pinto M, Pinto E, Silva A, Kijjoa A. Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand. Marine Drugs. 2007; 5(2):40-51.

Chicago/Turabian Style

Wattanadilok, Rawiwan; Sawangwong, Pichan; Rodrigues, Cátia; Cidade, Honorina; Pinto, Madalena; Pinto, Eugenia; Silva, Artur; Kijjoa, Anake. 2007. "Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand." Mar. Drugs 5, no. 2: 40-51.



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