Mar. Drugs 2007, 5(2), 40-51; doi:10.3390/md502040
Article

Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand

Rawiwan Wattanadilok 1 , Pichan Sawangwong 2 , Cátia Rodrigues 4 , Honorina Cidade 4 , Madalena Pinto 4 , Eugenia Pinto 5 , Artur Silva 7  and Anake Kijjoa 3,* email
1 Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand 2 Department of Aquatic Science, Faculty of Sciences, Burapha University, Bangsaen, Chonburi 20131, Thailand 3 Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal 4 Laboratório de Química Orgânica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal 5 Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal 6 Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto (CEQOFFUP), Rua Aníbal Cunha 164, 4050-047 Porto, Portugal 7 Departamento de Química, Universidade de Aveiro, 4810-1933 Aveiro, Portugal 8 ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal
* Author to whom correspondence should be addressed.
Received: 31 May 2007 / Accepted: 23 June 2007 / Published: 25 June 2007
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Abstract: A new compound maleimide-5-oxime was isolated, together with 3,4- dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(-) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi.
Keywords: Haliclona baeri; Haliclona cymaeformis; tetillapyrone; nortetillapyrone; antifungal activity; dermatophytes

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Cite This Article

MDPI and ACS Style

Wattanadilok, R.; Sawangwong, P.; Rodrigues, C.; Cidade, H.; Pinto, M.; Pinto, E.; Silva, A.; Kijjoa, A. Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand. Mar. Drugs 2007, 5, 40-51.

AMA Style

Wattanadilok R, Sawangwong P, Rodrigues C, Cidade H, Pinto M, Pinto E, Silva A, Kijjoa A. Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand. Marine Drugs. 2007; 5(2):40-51.

Chicago/Turabian Style

Wattanadilok, Rawiwan; Sawangwong, Pichan; Rodrigues, Cátia; Cidade, Honorina; Pinto, Madalena; Pinto, Eugenia; Silva, Artur; Kijjoa, Anake. 2007. "Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand." Mar. Drugs 5, no. 2: 40-51.

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