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New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels
AbstractSelective blockers of the N-type voltage-sensitive calcium (CaV) channels are useful in the management of severe chronic pain. Here, the structure and function characteristics of a novel N-type CaV channel blocker, SO-3, are reviewed. SO-3 is a 25-amino acid conopeptide originally derived from the venom of Conus striatus, and contains the same 4-loop, 6-cysteine framework (C-C-CC-C-C) as O-superfamily conotoxins. The synthetic SO-3 has high analgesic activity similar to ω-conotoxin MVIIA (MVIIA), a selective N-type CaV channel blocker approved in the USA and Europe for the alleviation of persistent pain states. In electrophysiological studies, SO-3 shows more selectivity towards the N-type CaV channels than MVIIA. The dissimilarity between SO-3 and MVIIA in the primary and tertiary structures is further discussed in an attempt to illustrate the difference in selectivity of SO-3 and MVIIA towards N-type CaV channels.
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Wen, L.; Yang, S.; Zhou, W.; Zhang, Y.; Huang, P. New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels. Mar. Drugs 2006, 4, 215-227.View more citation formats
Wen L, Yang S, Zhou W, Zhang Y, Huang P. New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels. Marine Drugs. 2006; 4(3):215-227.Chicago/Turabian Style
Wen, Lei; Yang, Sheng; Zhou, Wenxia; Zhang, Yongxiang; Huang, Peitang. 2006. "New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels." Mar. Drugs 4, no. 3: 215-227.