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Mar. Drugs 2006, 4(3), 215-227; doi:10.3390/md403215
Review

New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels

1,2, 1, 1, 1,*  and 3
Received: 10 March 2006; Accepted: 30 March 2006 / Published: 6 April 2006
(This article belongs to the Special Issue Marine Drugs and Ion Channels)
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Abstract: Selective blockers of the N-type voltage-sensitive calcium (CaV) channels are useful in the management of severe chronic pain. Here, the structure and function characteristics of a novel N-type CaV channel blocker, SO-3, are reviewed. SO-3 is a 25-amino acid conopeptide originally derived from the venom of Conus striatus, and contains the same 4-loop, 6-cysteine framework (C-C-CC-C-C) as O-superfamily conotoxins. The synthetic SO-3 has high analgesic activity similar to ω-conotoxin MVIIA (MVIIA), a selective N-type CaV channel blocker approved in the USA and Europe for the alleviation of persistent pain states. In electrophysiological studies, SO-3 shows more selectivity towards the N-type CaV channels than MVIIA. The dissimilarity between SO-3 and MVIIA in the primary and tertiary structures is further discussed in an attempt to illustrate the difference in selectivity of SO-3 and MVIIA towards N-type CaV channels.
Keywords: ω-conotoxins; SO-3; MVIIA; voltage-sensitive calcium channels; N-type calcium channel blockers; pain ω-conotoxins; SO-3; MVIIA; voltage-sensitive calcium channels; N-type calcium channel blockers; pain
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wen, L.; Yang, S.; Zhou, W.; Zhang, Y.; Huang, P. New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels. Mar. Drugs 2006, 4, 215-227.

AMA Style

Wen L, Yang S, Zhou W, Zhang Y, Huang P. New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels. Marine Drugs. 2006; 4(3):215-227.

Chicago/Turabian Style

Wen, Lei; Yang, Sheng; Zhou, Wenxia; Zhang, Yongxiang; Huang, Peitang. 2006. "New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels." Mar. Drugs 4, no. 3: 215-227.



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