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Mar. Drugs 2006, 4(3), 193-214; doi:10.3390/md403193

ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential

 and *
Institute for Molecular Bioscience, The University of Queensland, St Lucia, 4072, QLD, Australia
* Author to whom correspondence should be addressed.
Received: 16 February 2006 / Accepted: 28 February 2006 / Published: 6 April 2006
(This article belongs to the Special Issue Marine Drugs and Ion Channels)
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Highly selective N-type voltage-gated calcium (CaV) channel inhibitors from cone snail venom (the ω-conotoxins) have emerged as a new class of therapeutics for the treatment of chronic and neuropathic pain. Earlier in 2005, Prialt (Elan) or synthetic ω-conotoxin MVIIA, was the first ω-conotoxin to be approved by Food and Drug Administration for human use. This review compares the action of three ω-conotoxins, GVIA, MVIIA and CVID, describing their structure-activity relationships and potential as leads for the design of improved N-type therapeutics that are more useful in the treatment of chronic pain.
Keywords: ω-conotoxin; Structure-Activity relationship; pain ω-conotoxin; Structure-Activity relationship; pain
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schroeder, C.I.; Lewis, R.J. ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential. Mar. Drugs 2006, 4, 193-214.

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