Mar. Drugs 2006, 4(3), 228-254; doi:10.3390/md403228
Review

The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors

1 Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK 2 School of Chemistry, University of Bristol, Bristol BS8 1TS, UK
* Author to whom correspondence should be addressed.
Received: 25 January 2006; Accepted: 31 January 2006 / Published: 6 April 2006
(This article belongs to the Special Issue Marine Drugs and Ion Channels)
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Abstract: This chapter covers the chemistry and nicotinic pharmacology of naturally occurring homotropane alkaloids, with an emphasis of anatoxin-a. In addition to anatoxin-a, homoanatoxin and pinnamine, as well as the major classes of synthetic derivatives of anatoxin-a including UB-165, are discussed.
Keywords: anatoxin-a; homoanatoxin; UB165; pinnamine; homotropane; nicotinic acetylcholine receptor; pharmacophore

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MDPI and ACS Style

Wonnacott, S.; Gallagher, T. The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors. Mar. Drugs 2006, 4, 228-254.

AMA Style

Wonnacott S, Gallagher T. The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors. Marine Drugs. 2006; 4(3):228-254.

Chicago/Turabian Style

Wonnacott, Susan; Gallagher, Timothy. 2006. "The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors." Mar. Drugs 4, no. 3: 228-254.

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