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Mar. Drugs 2006, 4(3), 228-254; doi:10.3390/md403228
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The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors

1,*  and 2
Received: 25 January 2006 / Accepted: 31 January 2006 / Published: 6 April 2006
(This article belongs to the Special Issue Marine Drugs and Ion Channels)
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Abstract

This chapter covers the chemistry and nicotinic pharmacology of naturally occurring homotropane alkaloids, with an emphasis of anatoxin-a. In addition to anatoxin-a, homoanatoxin and pinnamine, as well as the major classes of synthetic derivatives of anatoxin-a including UB-165, are discussed.
Keywords: anatoxin-a; homoanatoxin; UB165; pinnamine; homotropane; nicotinic acetylcholine receptor; pharmacophore anatoxin-a; homoanatoxin; UB165; pinnamine; homotropane; nicotinic acetylcholine receptor; pharmacophore
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wonnacott, S.; Gallagher, T. The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors. Mar. Drugs 2006, 4, 228-254.

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