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Mar. Drugs 2006, 4(1), 9-14; doi:10.3390/md401009
Communication

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

1, 2, 1,3, 1, 1, 4, 1 and 2,*
Received: 18 January 2006 / Accepted: 21 February 2006 / Published: 21 February 2006
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Abstract

Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).
Keywords: Protein tyrosine phosphatases; TCPTP; Inhibitors; Manzamenones Protein tyrosine phosphatases; TCPTP; Inhibitors; Manzamenones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wakuda, Y.; Kubota, T.; Shima, H.; Okada, T.; Mitsuhashi, S.; Aoki, N.; Kikuchi, K.; Kobayashi, J. Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase. Mar. Drugs 2006, 4, 9-14.

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