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Mar. Drugs 2006, 4(1), 9-14; doi:10.3390/md401009
Communication

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

1, 2, 1,3, 1, 1, 4, 1 and 2,*
1 Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan 2 Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan 3 Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Miyagi 981- 1293, Japan 4 Department of Life Sciences, Faculty of Bioresources, Mie University, 1577 Kurimamachiya-cho, Tsu, Mie 514-8507 Japan
* Author to whom correspondence should be addressed.
Received: 18 January 2006 / Accepted: 21 February 2006 / Published: 21 February 2006
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Abstract

Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).
Keywords: Protein tyrosine phosphatases; TCPTP; Inhibitors; Manzamenones Protein tyrosine phosphatases; TCPTP; Inhibitors; Manzamenones
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wakuda, Y.; Kubota, T.; Shima, H.; Okada, T.; Mitsuhashi, S.; Aoki, N.; Kikuchi, K.; Kobayashi, J. Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase. Mar. Drugs 2006, 4, 9-14.

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