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Mar. Drugs 2006, 4(1), 9-14; doi:10.3390/md401009
Communication

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

1, 2, 1,3, 1, 1, 4, 1 and 2,*
1 Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan 2 Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan 3 Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Miyagi 981- 1293, Japan 4 Department of Life Sciences, Faculty of Bioresources, Mie University, 1577 Kurimamachiya-cho, Tsu, Mie 514-8507 Japan
* Author to whom correspondence should be addressed.
Received: 18 January 2006 / Accepted: 21 February 2006 / Published: 21 February 2006
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Abstract

Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).
Keywords: Protein tyrosine phosphatases; TCPTP; Inhibitors; Manzamenones Protein tyrosine phosphatases; TCPTP; Inhibitors; Manzamenones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wakuda, Y.; Kubota, T.; Shima, H.; Okada, T.; Mitsuhashi, S.; Aoki, N.; Kikuchi, K.; Kobayashi, J. Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase. Mar. Drugs 2006, 4, 9-14.

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