Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

doi:10.3390/md401009

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Mar. Drugs 2006, 4(1), 9-14; doi:10.3390/md401009

Communication

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

Yusuke Wakuda¹, Takaaki Kubota², Hiroshi Shima^1,3, Tadashi Okada¹, Shinya Mitsuhashi¹, Naohito Aoki⁴, Kunimi Kikuchi¹ and Jun\'ichi Kobayashi^2,*

¹ Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan ² Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan ³ Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Miyagi 981- 1293, Japan ⁴ Department of Life Sciences, Faculty of Bioresources, Mie University, 1577 Kurimamachiya-cho, Tsu, Mie 514-8507 Japan

* Author to whom correspondence should be addressed.

Received: 18 January 2006 / Accepted: 21 February 2006 / Published: 21 February 2006

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Abstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).

Keywords: Protein tyrosine phosphatases; TCPTP; Inhibitors; Manzamenones

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Cite This Article

MDPI and ACS Style

Wakuda, Y.; Kubota, T.; Shima, H.; Okada, T.; Mitsuhashi, S.; Aoki, N.; Kikuchi, K.; Kobayashi, J. Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase. Mar. Drugs 2006, 4, 9-14.

AMA Style

Wakuda Y, Kubota T, Shima H, Okada T, Mitsuhashi S, Aoki N, Kikuchi K, Kobayashi J. Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase. Marine Drugs. 2006; 4(1):9-14.

Chicago/Turabian Style

Wakuda, Yusuke; Kubota, Takaaki; Shima, Hiroshi; Okada, Tadashi; Mitsuhashi, Shinya; Aoki, Naohito; Kikuchi, Kunimi; Kobayashi, Jun\'ichi. 2006. "Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase." Mar. Drugs 4, no. 1: 9-14.

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