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Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
AbstractManzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).
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Wakuda, Y.; Kubota, T.; Shima, H.; Okada, T.; Mitsuhashi, S.; Aoki, N.; Kikuchi, K.; Kobayashi, J. Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase. Mar. Drugs 2006, 4, 9-14.View more citation formats
Wakuda Y, Kubota T, Shima H, Okada T, Mitsuhashi S, Aoki N, Kikuchi K, Kobayashi J. Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase. Marine Drugs. 2006; 4(1):9-14.Chicago/Turabian Style
Wakuda, Yusuke; Kubota, Takaaki; Shima, Hiroshi; Okada, Tadashi; Mitsuhashi, Shinya; Aoki, Naohito; Kikuchi, Kunimi; Kobayashi, Jun\'ichi. 2006. "Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase." Mar. Drugs 4, no. 1: 9-14.
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