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Mar. Drugs 2006, 4(1), 1-8; doi:10.3390/md401001
Article

Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.

1, 1, 2, 2, 2, 3, 3, 3, 4, 4, 5, 5, 6 and 1,*
1 Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil 2 Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12,D-27570 Bremerhaven, Germany 3 Faculdade de Ciências da Saúde, Universidade Metodista de Piracicaba, Piracaba, SP, Brazil 4 Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, Brazil 5 Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil 6 Museu Nacional, Universidade Federal do Rio de Janeiro, Quinta da Boa Vista, s/n, 20940-040, Rio de Janeiro, RJ, Brazil
* Author to whom correspondence should be addressed.
Received: 7 December 2005 / Accepted: 18 January 2006 / Published: 20 January 2006
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Abstract

Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and antibiotic-susceptible Escherichia coli and Candida albicans, as well as in antimycobacterial activity against Mycobacterium tuberculosis H37Rv bioassays. The results obtained indicated that cyclostellettamines display different antimicrobial activity depending on the alkyl-chain size, suggesting that, if a mechanism-of action is implied, it is dependent on the distance between the two pyridinium moieties of cyclostellettamines.
Keywords: alkaloids; antimycobacterial; antibacterial; Pachychalina sp.; sponge alkaloids; antimycobacterial; antibacterial; Pachychalina sp.; sponge
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

De Oliveira, J.H.H.L.; Seleghim, M.H.R.; Timm, C.; Grube, A.; Köck, M.; Nascimento, G.G.; Martins, A.C.T.; Silva, E.G.O.; De Souza, A.O.; Minarini, P.R.R.; Galetti, F.C.S.; Silva, C.L.; Hajdu, E.; Berlinck, R.G.S. Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.. Mar. Drugs 2006, 4, 1-8.

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