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Mar. Drugs 2006, 4(1), 15-21; doi:10.3390/md401015
Article

Effects of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated Promyelocytic Leukemia Cell Line

1,* , 2, 2, 2, 3, 1 and 2
1 Department of Pharmaceutical Sciences, Kyoritsu University of Pharmacy, Shibakoen, Minato-ku, Tokyo 105-8512, Japan 2 Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan 3 Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia
* Author to whom correspondence should be addressed.
Received: 28 December 2005 / Accepted: 17 February 2006 / Published: 21 February 2006
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Abstract

The effects of seven compounds 1-7, isolated from a tropical ascidian Lissoclinum cf. badium, on IL-8 production in PMA-stimulated HL-60 cells were examined. Lissoclibadins 2 (2) and 3 (3) and lissoclinotoxin F (5) increased the IL-8 production in a dose-dependent manner. Compounds 2 and 5 are structural isomers possessing dimeric structures of trans and cis-orientations, respectively, and showed a very similar activity on the induction of IL-8 levels. Compound 3 and lissoclinotoxin E (4) are also structural isomers having dimeric trans and cis-structures, respectively, but 4 did not induce the IL-8 production. Lissoclibadin 1 (1, trimeric compound) and two monomeric compounds (6 and 7) did not increase the IL-8 level. Therefore, the differences in their structures remarkably affected the IL-8 production activity, the inhibition of cell proliferation, and the survival of HL-60 cells. Lissoclibadin 2 was the most interesting compound of the seven metabolites tested in this study.
Keywords: Tropical ascidian; Lissoclinum cf. badium; Lissoclibadins; Lissoclinotoxins; IL- 8; HL-60 cells Tropical ascidian; Lissoclinum cf. badium; Lissoclibadins; Lissoclinotoxins; IL- 8; HL-60 cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Oda, T.; Fujiwara, T.; Liu, H.; Ukai, K.; Mangindaan, R.E.P.; Mochizuki, M.; Namikoshi, M. Effects of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated Promyelocytic Leukemia Cell Line. Mar. Drugs 2006, 4, 15-21.

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