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Mar. Drugs 2006, 4(1), 15-21; doi:10.3390/md401015
Article

Effects of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated Promyelocytic Leukemia Cell Line

1,* , 2, 2, 2, 3, 1 and 2
Received: 28 December 2005; Accepted: 17 February 2006 / Published: 21 February 2006
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Abstract: The effects of seven compounds 1-7, isolated from a tropical ascidian Lissoclinum cf. badium, on IL-8 production in PMA-stimulated HL-60 cells were examined. Lissoclibadins 2 (2) and 3 (3) and lissoclinotoxin F (5) increased the IL-8 production in a dose-dependent manner. Compounds 2 and 5 are structural isomers possessing dimeric structures of trans and cis-orientations, respectively, and showed a very similar activity on the induction of IL-8 levels. Compound 3 and lissoclinotoxin E (4) are also structural isomers having dimeric trans and cis-structures, respectively, but 4 did not induce the IL-8 production. Lissoclibadin 1 (1, trimeric compound) and two monomeric compounds (6 and 7) did not increase the IL-8 level. Therefore, the differences in their structures remarkably affected the IL-8 production activity, the inhibition of cell proliferation, and the survival of HL-60 cells. Lissoclibadin 2 was the most interesting compound of the seven metabolites tested in this study.
Keywords: Tropical ascidian; Lissoclinum cf. badium; Lissoclibadins; Lissoclinotoxins; IL- 8; HL-60 cells Tropical ascidian; Lissoclinum cf. badium; Lissoclibadins; Lissoclinotoxins; IL- 8; HL-60 cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Oda, T.; Fujiwara, T.; Liu, H.; Ukai, K.; Mangindaan, R.E.P.; Mochizuki, M.; Namikoshi, M. Effects of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated Promyelocytic Leukemia Cell Line. Mar. Drugs 2006, 4, 15-21.

AMA Style

Oda T, Fujiwara T, Liu H, Ukai K, Mangindaan REP, Mochizuki M, Namikoshi M. Effects of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated Promyelocytic Leukemia Cell Line. Marine Drugs. 2006; 4(1):15-21.

Chicago/Turabian Style

Oda, Taiko; Fujiwara, Takeshi; Liu, Hongwei; Ukai, Kazuyo; Mangindaan, Remy E.P.; Mochizuki, Masataka; Namikoshi, Michio. 2006. "Effects of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated Promyelocytic Leukemia Cell Line." Mar. Drugs 4, no. 1: 15-21.


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