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Mar. Drugs 2006, 4(1), 22-27; doi:10.3390/md401022
Article

Effects of bistheonellide A, an Actin-polymerization Inhibitor, on Chinese Hamster V79 Cells and on IL-8 Production in PMA-stimulated HL-60 Cells

1,2,* , 2, 2, 1 and 2
Received: 20 January 2006; Accepted: 21 February 2006 / Published: 21 February 2006
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Abstract: Bioassay-guided isolation from the ethanol extract of a marine sponge Theonella sp. collected in Palau yielded bistheonellide A, which strongly inhibited the colony formation of Chinese hamster V79 cells (EC50 = 6.8 nM). Bistheonellide A is an actinpolymerization inhibitor and was suggested to control cytokine production. Therefore, we attempted to detect an effect of this compound on IL-8 production in PMA-stimulated HL- 60 cells. Interestingly, bistheonellide A did not modulate the production of IL-8 under cytotoxic concentrations as determined by LDH analysis. Although the correlation between the inhibition of microtubule assembly and the stimulation of IL-8 production has been observed for several compounds, the polymerization of actin was not related to an IL-8 production in the case of bistheonellide A. It will be suggested that the actin polymerization is not involved in the IL-8 production system.
Keywords: Bistheonellide A; actin-polymerization inhibitor; IL-8; HL-60 cell; V79 cell Bistheonellide A; actin-polymerization inhibitor; IL-8; HL-60 cell; V79 cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Oda, T.; Xu, J.; Fujita, A.; Mochizuki, M.; Namikoshi, M. Effects of bistheonellide A, an Actin-polymerization Inhibitor, on Chinese Hamster V79 Cells and on IL-8 Production in PMA-stimulated HL-60 Cells. Mar. Drugs 2006, 4, 22-27.

AMA Style

Oda T, Xu J, Fujita A, Mochizuki M, Namikoshi M. Effects of bistheonellide A, an Actin-polymerization Inhibitor, on Chinese Hamster V79 Cells and on IL-8 Production in PMA-stimulated HL-60 Cells. Marine Drugs. 2006; 4(1):22-27.

Chicago/Turabian Style

Oda, Taiko; Xu, Jinzhong; Fujita, Ayako; Mochizuki, Masataka; Namikoshi, Michio. 2006. "Effects of bistheonellide A, an Actin-polymerization Inhibitor, on Chinese Hamster V79 Cells and on IL-8 Production in PMA-stimulated HL-60 Cells." Mar. Drugs 4, no. 1: 22-27.



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