Mar. Drugs 2006, 4(2), 28-36; doi:10.3390/md402028
Article

Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources

Hesham Fahmy 1,* email, Jordan K. Zjawiony 2,* email, Takao Konoshima 3 , Harukuni Tokuda 4 , Shabana Khan 5  and Sherief Khalifa 6
1 Department of Pharmaceutical Sciences, South Dakota State University, Box 2202C, Brookings, SD 57007, USA 2 Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA 3 Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan 4 Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachidori, Kamigyo-Ku, Kyoto 602-0841, Japan 5 National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677-1848, USA 6 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
* Authors to whom correspondence should be addressed.
Received: 7 March 2006 / Accepted: 21 March 2006 / Published: 24 March 2006
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Abstract: In the course of our continuing research in development and evaluation of novel skin cancer chemopreventive agents from marine sources, five semi-synthetic cembranoids derived from the marine natural product sarcophine, isolated from the soft coral Sarcophyton glaucum, were synthesized and shown to exhibit a remarkable chemopreventive activity in the in-vitro Epstein Barr Virus Early Antigen (EBV-EA) activation assay. These compounds were assayed in vivo using the two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator, and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by topical administration. They showed potent inhibition of both percentage incidence of skin tumor as well asthe multiplicity of skin tumors per mouse compared to untreated controls.Semi-synthetic Cembranoids from Marine Sources
Keywords: Cancer chemoprevention; Skin cancer; Cembranoids; Sarcophine; Sarcophyton glaucum

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MDPI and ACS Style

Fahmy, H.; Zjawiony, J.K.; Konoshima, T.; Tokuda, H.; Khan, S.; Khalifa, S. Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources. Mar. Drugs 2006, 4, 28-36.

AMA Style

Fahmy H, Zjawiony JK, Konoshima T, Tokuda H, Khan S, Khalifa S. Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources. Marine Drugs. 2006; 4(2):28-36.

Chicago/Turabian Style

Fahmy, Hesham; Zjawiony, Jordan K.; Konoshima, Takao; Tokuda, Harukuni; Khan, Shabana; Khalifa, Sherief. 2006. "Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources." Mar. Drugs 4, no. 2: 28-36.

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