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Mar. Drugs 2006, 4(2), 28-36; doi:10.3390/md402028
Article

Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources

1,* , 2,* , 3, 4, 5 and 6
1 Department of Pharmaceutical Sciences, South Dakota State University, Box 2202C, Brookings, SD 57007, USA 2 Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA 3 Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan 4 Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachidori, Kamigyo-Ku, Kyoto 602-0841, Japan 5 National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677-1848, USA 6 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
* Authors to whom correspondence should be addressed.
Received: 7 March 2006 / Accepted: 21 March 2006 / Published: 24 March 2006
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Abstract

In the course of our continuing research in development and evaluation of novel skin cancer chemopreventive agents from marine sources, five semi-synthetic cembranoids derived from the marine natural product sarcophine, isolated from the soft coral Sarcophyton glaucum, were synthesized and shown to exhibit a remarkable chemopreventive activity in the in-vitro Epstein Barr Virus Early Antigen (EBV-EA) activation assay. These compounds were assayed in vivo using the two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator, and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by topical administration. They showed potent inhibition of both percentage incidence of skin tumor as well asthe multiplicity of skin tumors per mouse compared to untreated controls.Semi-synthetic Cembranoids from Marine Sources
Keywords: Cancer chemoprevention; Skin cancer; Cembranoids; Sarcophine; Sarcophyton glaucum Cancer chemoprevention; Skin cancer; Cembranoids; Sarcophine; Sarcophyton glaucum
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fahmy, H.; Zjawiony, J.K.; Konoshima, T.; Tokuda, H.; Khan, S.; Khalifa, S. Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources. Mar. Drugs 2006, 4, 28-36.

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