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Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan
Department of Sciences, School of Education, Arts and Sciences, The State University of Zanzibar, P.O.Box 146, Zanzibar, Tanzania
Research and Development Centre for Oceanology LIPI, Jl. Pasir Putih 1, Ancor Timur, Jakarta 11048, Indonesia
Department of Chemistry, Lampung University, Bandar Lampung 35145, Indonesia
Department of Marine Science, Diponegoro University, Semarang, Central Java 50234, Indonesia
* Author to whom correspondence should be addressed.
Received: 24 January 2005; Accepted: 13 June 2005 / Published: 23 September 2005
Abstract: Two new tricyclic alkaloids, polycitorols A (1) and B (2) have been isolated along with the known lepadiformine (3) from a marine ascidian of the family Polycitoridae. The structures of the new compounds were elucidated by analysis of NMR data and comparison with those of 3 and other related compounds [1-5]. Compounds 1 and 2 are closely related to cylindricines A and B, lacking C-4 oxygenation found in cylindricines and having a butyl instead of a hexyl appendage. NOE experiments on compounds 1 and 2 suggested the A/B ring fusion to be cis.
Keywords: polycitorols; Polycitoridae; tricyclic alkaloids; ascidian; polycyclic alkaloids
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Issa, H.H.; Tanaka, J.; Rachmat, R.; Setiawan, A.; Trianto, A.; Higa, T. Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian. Mar. Drugs 2005, 3, 78-83.
Issa HH, Tanaka J, Rachmat R, Setiawan A, Trianto A, Higa T. Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian. Marine Drugs. 2005; 3(3):78-83.
Issa, Hamad H.; Tanaka, Junichi; Rachmat, Rachmaniar; Setiawan, Andi; Trianto, Agus; Higa, Tatsuo. 2005. "Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian." Mar. Drugs 3, no. 3: 78-83.