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Mar. Drugs 2005, 3(3), 78-83; doi:10.3390/md303078
Article

Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian

1,2, 1,* , 3, 4, 5 and 2
Received: 24 January 2005 / Accepted: 13 June 2005 / Published: 23 September 2005
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Abstract

Two new tricyclic alkaloids, polycitorols A (1) and B (2) have been isolated along with the known lepadiformine (3) from a marine ascidian of the family Polycitoridae. The structures of the new compounds were elucidated by analysis of NMR data and comparison with those of 3 and other related compounds [1-5]. Compounds 1 and 2 are closely related to cylindricines A and B, lacking C-4 oxygenation found in cylindricines and having a butyl instead of a hexyl appendage. NOE experiments on compounds 1 and 2 suggested the A/B ring fusion to be cis.
Keywords: polycitorols; Polycitoridae; tricyclic alkaloids; ascidian; polycyclic alkaloids polycitorols; Polycitoridae; tricyclic alkaloids; ascidian; polycyclic alkaloids
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Issa, H.H.; Tanaka, J.; Rachmat, R.; Setiawan, A.; Trianto, A.; Higa, T. Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian. Mar. Drugs 2005, 3, 78-83.

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