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Mar. Drugs 2005, 3(3), 78-83; doi:10.3390/md303078

Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian

1,2, 1,* , 3, 4, 5 and 2
1 Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan 2 Department of Sciences, School of Education, Arts and Sciences, The State University of Zanzibar, P.O.Box 146, Zanzibar, Tanzania 3 Research and Development Centre for Oceanology LIPI, Jl. Pasir Putih 1, Ancor Timur, Jakarta 11048, Indonesia 4 Department of Chemistry, Lampung University, Bandar Lampung 35145, Indonesia 5 Department of Marine Science, Diponegoro University, Semarang, Central Java 50234, Indonesia
* Author to whom correspondence should be addressed.
Received: 24 January 2005 / Accepted: 13 June 2005 / Published: 23 September 2005
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Two new tricyclic alkaloids, polycitorols A (1) and B (2) have been isolated along with the known lepadiformine (3) from a marine ascidian of the family Polycitoridae. The structures of the new compounds were elucidated by analysis of NMR data and comparison with those of 3 and other related compounds [1-5]. Compounds 1 and 2 are closely related to cylindricines A and B, lacking C-4 oxygenation found in cylindricines and having a butyl instead of a hexyl appendage. NOE experiments on compounds 1 and 2 suggested the A/B ring fusion to be cis.
Keywords: polycitorols; Polycitoridae; tricyclic alkaloids; ascidian; polycyclic alkaloids polycitorols; Polycitoridae; tricyclic alkaloids; ascidian; polycyclic alkaloids
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Issa, H.H.; Tanaka, J.; Rachmat, R.; Setiawan, A.; Trianto, A.; Higa, T. Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian. Mar. Drugs 2005, 3, 78-83.

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