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• Issa, HH.
• Tanaka, J
• Rachmat, R
• Setiawan, A
• Trianto, A
• Higa, T
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• Issa, HH.
• Tanaka, J
• Rachmat, R
• Setiawan, A
• Trianto, A
• Higa, T
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• Tanaka, J
• Rachmat, R
• Setiawan, A
• Trianto, A
• Higa, T

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Mar. Drugs 2005, 3(3), 78-83; doi:10.3390/md303078

Article

Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian

Hamad H. Issa ^1,2 , Junichi Tanaka ^1,* , Rachmaniar Rachmat ³ , Andi Setiawan ⁴ , Agus Trianto ⁵  and Tatsuo Higa ²

¹ Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan ² Department of Sciences, School of Education, Arts and Sciences, The State University of Zanzibar, P.O.Box 146, Zanzibar, Tanzania ³ Research and Development Centre for Oceanology LIPI, Jl. Pasir Putih 1, Ancor Timur, Jakarta 11048, Indonesia ⁴ Department of Chemistry, Lampung University, Bandar Lampung 35145, Indonesia ⁵ Department of Marine Science, Diponegoro University, Semarang, Central Java 50234, Indonesia

* Author to whom correspondence should be addressed.

Received: 24 January 2005 / Accepted: 13 June 2005 / Published: 23 September 2005

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Abstract: Two new tricyclic alkaloids, polycitorols A (1) and B (2) have been isolated along with the known lepadiformine (3) from a marine ascidian of the family Polycitoridae. The structures of the new compounds were elucidated by analysis of NMR data and comparison with those of 3 and other related compounds [1-5]. Compounds 1 and 2 are closely related to cylindricines A and B, lacking C-4 oxygenation found in cylindricines and having a butyl instead of a hexyl appendage. NOE experiments on compounds 1 and 2 suggested the A/B ring fusion to be cis.

Keywords: polycitorols; Polycitoridae; tricyclic alkaloids; ascidian; polycyclic alkaloids

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