Next Article in Journal
Luteophanol D, New Polyhydroxyl Metabolite from Marine Dinoflagellate Amphidinium sp.
Previous Article in Journal
Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian
Mar. Drugs 2005, 3(3), 84-111; doi:10.3390/md303084

Sterol Ring System Oxidation Pattern in Marine Sponges

* ,  and
School of Chemistry, Andhra University, Visakhapatnam-530 003, India
* Author to whom correspondence should be addressed.
Received: 31 January 2005 / Accepted: 7 June 2005 / Published: 7 June 2005
View Full-Text   |   Download PDF [212 KB, uploaded 24 February 2015]   |   Browse Figures


The marine sponges (Porifera) are a unique group of sedentary organisms from which several novel natural products are reported, many of which have useful biological activities. In producing unusual sterols, they occupy a preeminent position among the various groups of organisms. The polar sterols of sponges reported as at the end of the year 2002 number about 250; their ring structure changing a hundred times. The oxidation pattern in the sterol ring system, from the point of view of biogenesis seems to be mainly of four types. Each sponge species is able to produce sterols fitting into one of the four main biogenetic pathways viz., (i) 3β-hydroxy-Δ5-sterol pathway, (ii) 3β-hydroxy-Δ7-sterol pathway, (iii) 3β-hydroxy-Δ5,7-sterol pathway, and (iv) 3α-hydroxy sterol pathway.
Keywords: Marine sponges; Polar sterols; Unusual sterols; Ring system; Oxidation pattern Marine sponges; Polar sterols; Unusual sterols; Ring system; Oxidation pattern
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Sarma, N.S.; Krishna, M.S.R.; Rao, S.R. Sterol Ring System Oxidation Pattern in Marine Sponges. Mar. Drugs 2005, 3, 84-111.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert