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Mar. Drugs 2005, 3(2), 64-73; doi:10.3390/md302064
Article

Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line

1,* , 4, 4, 5, 3 and 2
1 Department of Basic Biological Sciences, Kyoritsu College of Pharmacy, Shibakoen 1-chome, 5-30, Minato-ku, Tokyo, 105-8512, Japan 2 Department of Biochemistry, Kyoritsu College of Pharmacy, Shibakoen 1-chome, 5-30, Minato-ku, Tokyo, 105-8512, Japan 3 Institute of Radiopharmaceutical Chemistry, Kyoritsu College of Pharmacy, Shibakoen 1-chome, 5-30, Minato-ku, Tokyo, 105-8512, Japan 4 Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan 5 Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113- 0032, Japan
* Author to whom correspondence should be addressed.
Received: 4 March 2005 / Accepted: 2 June 2005 / Published: 2 June 2005
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Abstract

Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at noncytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.
Keywords: verrucarin A; MAP kinase; HL-60; p38-phosphorylation; JNKphosphorylation verrucarin A; MAP kinase; HL-60; p38-phosphorylation; JNKphosphorylation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Oda, T.; Namikoshi, M.; Akano, K.; Kobayashi, H.; Honma, Y.; Kasahara, T. Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line. Mar. Drugs 2005, 3, 64-73.

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