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Mar. Drugs 2004, 2(4), 176-184; doi:10.3390/md204176

1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel

1
Department of Chemistry, University of California, Davis, CA 95616, USA
2
Department of Molecular Biosciences, University of California, Davis, CA 95616, USA
*
Author to whom correspondence should be addressed.
Received: 29 July 2004 / Accepted: 14 October 2004 / Published: 25 November 2004
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Abstract

Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM).
Keywords: Bromotyrosine; calcium channel; Porifera; ryanodine receptor Bromotyrosine; calcium channel; Porifera; ryanodine receptor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Masuno, M.N.; Hoepker, A.C.; Pessah, I.N.; Molinski, T.F. 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel. Mar. Drugs 2004, 2, 176-184.

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