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Mar. Drugs 2004, 2(4), 176-184; doi:10.3390/md204176
Article

1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel

1, 1, 2 and 1,*
Received: 29 July 2004 / Accepted: 14 October 2004 / Published: 25 November 2004
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Abstract

Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM).
Keywords: Bromotyrosine; calcium channel; Porifera; ryanodine receptor Bromotyrosine; calcium channel; Porifera; ryanodine receptor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Masuno, M.N.; Hoepker, A.C.; Pessah, I.N.; Molinski, T.F. 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel. Mar. Drugs 2004, 2, 176-184.

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