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Mar. Drugs 2004, 2(4), 170-175; doi:10.3390/md204170
Article

Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells

* , ,  and
Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
* Author to whom correspondence should be addressed.
Received: 21 August 2004 / Accepted: 10 October 2004 / Published: 25 November 2004
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Abstract

The extract of the sea hare, Aplysia kurodai, showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded two active compounds, which were subsequently identified to be parguerol and isoparguerol by spectroscopic analysis. It was found that both parguerol and isoparguerol induced neurite outgrowth in PC-12 cells at concentrations of 25 and 50 μM, respectively.
Keywords: neurotrophic; parguerol; isoparguerol; sea hare neurotrophic; parguerol; isoparguerol; sea hare
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tsukamoto, S.; Yamashita, Y.; Yoshida, T.; Ohta, T. Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells. Mar. Drugs 2004, 2, 170-175.

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