Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells

doi:10.3390/md204170

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Mar. Drugs 2004, 2(4), 170-175; doi:10.3390/md204170

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Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells

Sachiko Tsukamoto* , Yuko Yamashita, Takushi Yoshida and Tomihisa Ohta

Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan

* Author to whom correspondence should be addressed.

Received: 21 August 2004 / Accepted: 10 October 2004 / Published: 25 November 2004

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Abstract: The extract of the sea hare, Aplysia kurodai, showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded two active compounds, which were subsequently identified to be parguerol and isoparguerol by spectroscopic analysis. It was found that both parguerol and isoparguerol induced neurite outgrowth in PC-12 cells at concentrations of 25 and 50 μM, respectively.

Keywords: neurotrophic; parguerol; isoparguerol; sea hare

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MDPI and ACS Style

Tsukamoto, S.; Yamashita, Y.; Yoshida, T.; Ohta, T. Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells. Mar. Drugs 2004, 2, 170-175.

AMA Style

Tsukamoto S., Yamashita Y., Yoshida T., Ohta T. Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells. Marine Drugs. 2004; 2(4):170-175.

Chicago/Turabian Style

Tsukamoto, Sachiko; Yamashita, Yuko; Yoshida, Takushi; Ohta, Tomihisa. 2004. "Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells." Mar. Drugs 2, no. 4: 170-175.

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