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New Alkaloids from the Mediterranean Sponge Hamigera hamigera
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstr 1, Geb. 26.23, 40225 Düsseldorf, Germany
Gesellschaft für Biotechnologische Forschung, Mascheroder Weg 1, 38124 Braunschweig, Germany
Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
* Author to whom correspondence should be addressed.
Received: 30 April 2004; Accepted: 27 May 2004 / Published: 25 August 2004
Abstract: The Mediterranean sponge Hamigera hamigera (family Anchinoideae) was studied since its total extract showed deterrent activity in a fish feeding assay. Eight compounds were isolated from the biologically active fractions and four of these proved to be new natural products, hamigeroxalamic acid (1), hamigeramine (2), hamigeramide (3) and hamiguanosinol (5). The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry .
Keywords: Hamigera hamigera; hamigeroxalamic acid; hamigeramime; hamigeramide; hamiguanosinol
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Hassan, W.; Edrada, R.; Ebel, R.; Wray, V.; Proksch, P. New Alkaloids from the Mediterranean Sponge Hamigera hamigera. Mar. Drugs 2004, 2, 88-100.
Hassan W, Edrada R, Ebel R, Wray V, Proksch P. New Alkaloids from the Mediterranean Sponge Hamigera hamigera. Marine Drugs. 2004; 2(3):88-100.
Hassan, Wafaa; Edrada, RuAngelie; Ebel, Rainer; Wray, Victor; Proksch, Peter. 2004. "New Alkaloids from the Mediterranean Sponge Hamigera hamigera." Mar. Drugs 2, no. 3: 88-100.