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Mar. Drugs 2004, 2(3), 88-100; doi:10.3390/md203088

New Alkaloids from the Mediterranean Sponge Hamigera hamigera

Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstr 1, Geb. 26.23, 40225 Düsseldorf, Germany
Gesellschaft für Biotechnologische Forschung, Mascheroder Weg 1, 38124 Braunschweig, Germany
Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
Author to whom correspondence should be addressed.
Received: 30 April 2004 / Accepted: 27 May 2004 / Published: 25 August 2004
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The Mediterranean sponge Hamigera hamigera (family Anchinoideae) was studied since its total extract showed deterrent activity in a fish feeding assay. Eight compounds were isolated from the biologically active fractions and four of these proved to be new natural products, hamigeroxalamic acid (1), hamigeramine (2), hamigeramide (3) and hamiguanosinol (5). The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry .
Keywords: Hamigera hamigera; hamigeroxalamic acid; hamigeramime; hamigeramide; hamiguanosinol Hamigera hamigera; hamigeroxalamic acid; hamigeramime; hamigeramide; hamiguanosinol
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hassan, W.; Edrada, R.; Ebel, R.; Wray, V.; Proksch, P. New Alkaloids from the Mediterranean Sponge Hamigera hamigera. Mar. Drugs 2004, 2, 88-100.

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