New Alkaloids from the Mediterranean Sponge Hamigera hamigera

doi:10.3390/md203088

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Mar. Drugs 2004, 2(3), 88-100; doi:10.3390/md203088

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New Alkaloids from the Mediterranean Sponge Hamigera hamigera

Wafaa Hassan^1,3, RuAngelie Edrada¹, Rainer Ebel¹, Victor Wray² and Peter Proksch^1,*

¹ Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstr 1, Geb. 26.23, 40225 Düsseldorf, Germany ² Gesellschaft für Biotechnologische Forschung, Mascheroder Weg 1, 38124 Braunschweig, Germany ³ Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

* Author to whom correspondence should be addressed.

Received: 30 April 2004 / Accepted: 27 May 2004 / Published: 25 August 2004

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Abstract: The Mediterranean sponge Hamigera hamigera (family Anchinoideae) was studied since its total extract showed deterrent activity in a fish feeding assay. Eight compounds were isolated from the biologically active fractions and four of these proved to be new natural products, hamigeroxalamic acid (1), hamigeramine (2), hamigeramide (3) and hamiguanosinol (5). The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry .

Keywords: Hamigera hamigera; hamigeroxalamic acid; hamigeramime; hamigeramide; hamiguanosinol

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Cite This Article

MDPI and ACS Style

Hassan, W.; Edrada, R.; Ebel, R.; Wray, V.; Proksch, P. New Alkaloids from the Mediterranean Sponge Hamigera hamigera. Mar. Drugs 2004, 2, 88-100.

AMA Style

Hassan W., Edrada R., Ebel R., Wray V., Proksch P. New Alkaloids from the Mediterranean Sponge Hamigera hamigera. Marine Drugs. 2004; 2(3):88-100.

Chicago/Turabian Style

Hassan, Wafaa; Edrada, RuAngelie; Ebel, Rainer; Wray, Victor; Proksch, Peter. 2004. "New Alkaloids from the Mediterranean Sponge Hamigera hamigera." Mar. Drugs 2, no. 3: 88-100.

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