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Mar. Drugs 2004, 2(3), 101-107; doi:10.3390/md203101

Bioactive Chromodorolide Diterpenes from an Aplysillid Sponge

1, 1, 1, 2 and 3,*
1 Natural Products Research Unit, Department of Chemistry, Chulalongkorn University, Bangkok 10330, Thailand 2 CSIRO Livestock Industries, Queensland Bioscience Precinct, Brisbane 4067, Australia 3 Department of Chemistry, School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia
* Author to whom correspondence should be addressed.
Received: 7 May 2004 / Accepted: 1 August 2004 / Published: 25 August 2004
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The known chromodorolides A (1) and B (2), and a new derivative chromodorolide C (3) have been isolated from an Australian sponge and characterized by 1D and 2D NMR experiments. The chromodorolides exhibited significant cytotoxicity against the P388 mouse leukaemia cell line, and also showed activity against the freeliving larval stages of the parasitic nematodes Haemonchus contortus and Trichostrongylus colubriformis.
Keywords: Marine sponges; secondary metabolites; diterpenes; chromodoranes; anthelmintic activity Marine sponges; secondary metabolites; diterpenes; chromodoranes; anthelmintic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rungprom, W.; Chavasiri, W.; Kokpol, U.; Kotze, A.; Garson, M.J. Bioactive Chromodorolide Diterpenes from an Aplysillid Sponge. Mar. Drugs 2004, 2, 101-107.

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