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• Rungprom, W
• Chavasiri, W
• Kokpol, U
• Kotze, A
• Garson, MJ.
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• Chavasiri, W
• Kokpol, U
• Kotze, A
• Garson, MJ.
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• Chavasiri, W
• Kokpol, U
• Kotze, A
• Garson, MJ.

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Mar. Drugs 2004, 2(3), 101-107; doi:10.3390/md203101

Article

Bioactive Chromodorolide Diterpenes from an Aplysillid Sponge

Wimolpun Rungprom¹ , Warinthorn Chavasiri¹ , Udom Kokpol¹ , Andrew Kotze²  and Mary J. Garson^3,*

¹ Natural Products Research Unit, Department of Chemistry, Chulalongkorn University, Bangkok 10330, Thailand ² CSIRO Livestock Industries, Queensland Bioscience Precinct, Brisbane 4067, Australia ³ Department of Chemistry, School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia

* Author to whom correspondence should be addressed.

Received: 7 May 2004 / Accepted: 1 August 2004 / Published: 25 August 2004

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Abstract: The known chromodorolides A (1) and B (2), and a new derivative chromodorolide C (3) have been isolated from an Australian sponge and characterized by 1D and 2D NMR experiments. The chromodorolides exhibited significant cytotoxicity against the P388 mouse leukaemia cell line, and also showed activity against the freeliving larval stages of the parasitic nematodes Haemonchus contortus and Trichostrongylus colubriformis.

Keywords: Marine sponges; secondary metabolites; diterpenes; chromodoranes; anthelmintic activity

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