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Mar. Drugs 2018, 16(9), 311; https://doi.org/10.3390/md16090311

Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi

1
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
2
Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China
3
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China
4
Key Laboratory of Inorganic-Organic Hybrid Functional Materials Chemistry (Tianjin Normal University), Ministry of Education, Tianjin 300387, China
*
Authors to whom correspondence should be addressed.
Received: 9 July 2018 / Revised: 29 August 2018 / Accepted: 31 August 2018 / Published: 3 September 2018
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Abstract

Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%. View Full-Text
Keywords: marine natural products; naamines; naamidines; anti-tobacco mosaic virus (TMV) activity; fungicidal activity marine natural products; naamines; naamidines; anti-tobacco mosaic virus (TMV) activity; fungicidal activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guo, P.; Li, G.; Liu, Y.; Lu, A.; Wang, Z.; Wang, Q. Naamines and Naamidines as Novel Agents against a Plant Virus and Phytopathogenic Fungi. Mar. Drugs 2018, 16, 311.

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