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Mar. Drugs 2018, 16(4), 103; https://doi.org/10.3390/md16040103

Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla

1,2
,
1,2, 3
,
1,2,4
,
1,2,4
and
1,2,4,*
1
State Key Laboratory of Drug Research, Shanghai Institute of MateriaMedica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China
2
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China
3
Syngenta, Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
4
Open Studio for Druggability Research of Marine Lead Compounds, Qingdao National Laboratory for Marine Science and Technology, 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China
*
Author to whom correspondence should be addressed.
Received: 11 January 2018 / Revised: 16 March 2018 / Accepted: 23 March 2018 / Published: 25 March 2018
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Abstract

A new prenyleudesmane type diterpene, sinupol (8), and a new capnosane type diterpenoid, sinulacetate (9), were isolated from the Xisha soft coral Sinularia polydactyla along with five known related diterpenes (47 and 10). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis, the comparison of their NMR data with those of related compounds, and time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations. Both new compounds (8 and 9) exhibited promising inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a potential drug target for the treatment of type II diabetes and obesity. View Full-Text
Keywords: Sinularia polydactyla; diterpenoids; PTP1B inhibitory activity Sinularia polydactyla; diterpenoids; PTP1B inhibitory activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ye, F.; Zhu, Z.-D.; Gu, Y.-C.; Li, J.; Zhu, W.-L.; Guo, Y.-W. Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla. Mar. Drugs 2018, 16, 103.

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