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Mar. Drugs 2017, 15(8), 259; doi:10.3390/md15080259

Identification and Antifungal Activity of Compounds from the Mangrove Endophytic Fungus Aspergillus clavatus R7

1
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China
2
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
*
Authors to whom correspondence should be addressed.
Received: 17 July 2017 / Accepted: 17 August 2017 / Published: 19 August 2017
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Abstract

Two new coumarin derivatives, 4,4′-dimethoxy-5,5′-dimethyl-7,7′-oxydicoumarin (1), 7-(γ,γ-dimethylallyloxy)-5-methoxy-4-methylcoumarin (2), a new chromone derivative, (S)-5-hydroxy-2,6-dimethyl-4H-furo[3,4-g]benzopyran-4,8(6H)-dione (5), and a new sterone derivative, 24-hydroxylergosta-4,6,8(14),22-tetraen-3-one (6), along with two known bicoumarins, kotanin (3) and orlandin (4), were isolated from an endophytic fungus Aspergillus clavatus (collection No. R7), isolated from the root of Myoporum bontioides collected from Leizhou Peninsula, China. Their structures were elucidated using 1D- and 2D- NMR spectroscopy, and HRESIMS. The absolute configuration of compound 5 was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Compound 6 significantly inhibited the plant pathogenic fungi Fusarium oxysporum, Colletotrichum musae and Penicillium italicum, compound 5 significantly inhibited Colletotrichum musae, and compounds 1, 3 and 4 greatly inhibited Fusarium oxysporum, showing the antifungal activities higher than those of the positive control, triadimefon. View Full-Text
Keywords: mangrove endophytic fungus; coumarin; chromone; sterone; antifungal activity; Aspergillus clavatus mangrove endophytic fungus; coumarin; chromone; sterone; antifungal activity; Aspergillus clavatus
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    Description: The NMR and MS spectra of compounds 1, 2, 5 and 6

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MDPI and ACS Style

Li, W.; Xiong, P.; Zheng, W.; Zhu, X.; She, Z.; Ding, W.; Li, C. Identification and Antifungal Activity of Compounds from the Mangrove Endophytic Fungus Aspergillus clavatus R7. Mar. Drugs 2017, 15, 259.

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