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Mar. Drugs 2017, 15(8), 260; doi:10.3390/md15080260

5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34

1
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315211, China
2
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA
3
Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University, Ningbo 315211, China
4
Ocean College, Zhejiang University, Hangzhou 310058, China
5
School of Medicine, Ningbo University, Ningbo 315211, China
6
Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, College of Pharmacy, Jinan University, Guangzhou 510632, China
*
Authors to whom correspondence should be addressed.
Received: 17 May 2017 / Accepted: 16 August 2017 / Published: 19 August 2017
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes II, 2017)
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Abstract

Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 14 were characterized using comprehensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison of electronic circular dichroism (ECD) spectra with literature values used for the reported analogue, cyclopenicillone (5), which was not isolated in this research. Compound 1 was shown to scavenge 2,2-diphenyl-1-picrylhydrazyl free radicals, and decrease β-amyloid (Aβ) fibrillization in vitro. Moreover, 1 significantly reduced H2O2-induced neurotoxicity in SH-SY5Y cells. These findings suggested that compound 1, a newly discovered cyclopentenone, has moderate anti-oxidative, anti-Aβ fibrillization properties and neuroprotective effects, and might be a good free radical scavenger. View Full-Text
Keywords: sponge-derived fungus; cyclopentenone; Trichoderma sp. HPQJ-34; Alzheimer’s disease sponge-derived fungus; cyclopentenone; Trichoderma sp. HPQJ-34; Alzheimer’s disease
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Fang, F.; Zhao, J.; Ding, L.; Huang, C.; Naman, C.B.; He, S.; Wu, B.; Zhu, P.; Luo, Q.; Gerwick, W.H.; Yan, X.; Wang, Q.; Zhang, Z.; Cui, W. 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34. Mar. Drugs 2017, 15, 260.

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