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Mar. Drugs 2017, 15(5), 128; doi:10.3390/md15050128

Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004

1
Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, 28 Luhuitou Road, Sanya 572000, China
2
Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
3
Imaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
4
Physical Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
5
Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
6
College of Life Science, Shenzhen University, 3688 Nanhai Ave, Shenzhen 518060, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul Long
Received: 7 April 2017 / Revised: 25 April 2017 / Accepted: 26 April 2017 / Published: 29 April 2017
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Abstract

Eleven new depsides—thielavins W–Z (14) and thielavins Z1–Z7 (511)—and also four known thielavins—A, H, J, and K (1215)—were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1–3 and 6–13 were active, with EC50 values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 13 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids. View Full-Text
Keywords: Marine-derived fungus; Thielavia sp.; antifouling; Balanus (=Amphibalanus) amphitrite; thielavins Marine-derived fungus; Thielavia sp.; antifouling; Balanus (=Amphibalanus) amphitrite; thielavins
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Han, Z.; Li, Y.-X.; Liu, L.-L.; Lu, L.; Guo, X.-R.; Zhang, X.-X.; Zhang, X.-Y.; Qi, S.-H.; Xu, Y.; Qian, P.-Y. Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004. Mar. Drugs 2017, 15, 128.

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