Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004
AbstractEleven new depsides—thielavins W–Z (1–4) and thielavins Z1–Z7 (5–11)—and also four known thielavins—A, H, J, and K (12–15)—were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1–3 and 6–13 were active, with EC50 values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 1–3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids. View Full-Text
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Han, Z.; Li, Y.-X.; Liu, L.-L.; Lu, L.; Guo, X.-R.; Zhang, X.-X.; Zhang, X.-Y.; Qi, S.-H.; Xu, Y.; Qian, P.-Y. Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004. Mar. Drugs 2017, 15, 128.
Han Z, Li Y-X, Liu L-L, Lu L, Guo X-R, Zhang X-X, Zhang X-Y, Qi S-H, Xu Y, Qian P-Y. Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004. Marine Drugs. 2017; 15(5):128.Chicago/Turabian Style
Han, Zhuang; Li, Yong-Xin; Liu, Ling-Li; Lu, Liang; Guo, Xian-Rong; Zhang, Xi-Xiang; Zhang, Xiao-Yong; Qi, Shu-Hua; Xu, Ying; Qian, Pei-Yuan. 2017. "Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004." Mar. Drugs 15, no. 5: 128.
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