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Mar. Drugs 2017, 15(5), 127; doi:10.3390/md15050127

Bioresponsive Materials for Drug Delivery Based on Carboxymethyl Chitosan/Poly(γ-Glutamic Acid) Composite Microparticles

School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China
These authors contributed equally to this work.
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Academic Editors: Hitoshi Sashiwa and David Harding
Received: 27 March 2017 / Revised: 14 April 2017 / Accepted: 17 April 2017 / Published: 28 April 2017
(This article belongs to the Special Issue Marine Chitin)
View Full-Text   |   Download PDF [11958 KB, uploaded 28 April 2017]   |  

Abstract

Carboxymethyl chitosan (CMCS) microparticles are a potential candidate for hemostatic wound dressing. However, its low swelling property limits its hemostatic performance. Poly(γ-glutamic acid) (PGA) is a natural polymer with excellent hydrophilicity. In the current study, a novel CMCS/PGA composite microparticles with a dual-network structure was prepared by the emulsification/internal gelation method. The structure and thermal stability of the composite were determined by Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). The effects of preparation conditions on the swelling behavior of the composite were investigated. The results indicate that the swelling property of CMCS/PGA composite microparticles is pH sensitive. Levofloxacin (LFX) was immobilized in the composite microparticles as a model drug to evaluate the drug delivery performance of the composite. The release kinetics of LFX from the composite microparticles with different structures was determined. The results suggest that the CMCS/PGA composite microparticles are an excellent candidate carrier for drug delivery. View Full-Text
Keywords: carboxymethyl chitosan; poly(γ-glutamic acid); microparticle; drug release carboxymethyl chitosan; poly(γ-glutamic acid); microparticle; drug release
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yan, X.; Tong, Z.; Chen, Y.; Mo, Y.; Feng, H.; Li, P.; Qu, X.; Jin, S. Bioresponsive Materials for Drug Delivery Based on Carboxymethyl Chitosan/Poly(γ-Glutamic Acid) Composite Microparticles. Mar. Drugs 2017, 15, 127.

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