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Mar. Drugs 2017, 15(2), 47; doi:10.3390/md15020047

Antibacterial Activities of Bacteria Isolated from the Marine Sponges Isodictya compressa and Higginsia bidentifera Collected from Algoa Bay, South Africa

1
Institute for Microbial Biotechnology and Metagenomics (IMBM), Department of Biotechnology, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, Cape Town, South Africa
2
Department of Zoology, Nelson Mandela Metropolitan University, University Way, Port Elizabeth 6031, South Africa
3
South African Institute for Aquatic Biodiversity (SAIAB), Somerset Street, Grahamstown 6139, South Africa
4
Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, Cape Town, South Africa
*
Author to whom correspondence should be addressed.
Received: 8 November 2016 / Accepted: 30 January 2017 / Published: 17 February 2017
(This article belongs to the Special Issue Antibacterial Marine Pharmacology)
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Abstract

Due to the rise in multi‐drug resistant pathogens and other diseases, there is renewed interest in marine sponge endosymbionts as a rich source of natural products (NPs). The South African marine environment is rich in marine biota that remains largely unexplored and may represent an important source for the discovery of novel NPs. We first investigated the bacterial diversity associated with five South African marine sponges, whose microbial populations had not previously been investigated, and select the two sponges (Isodictya compressa and Higginsia bidentifera) with highest species richness to culture bacteria. By employing 33 different growth conditions 415 sponge‐associated bacterial isolates were cultured and screened for antibacterial activity. Thirty‐five isolates showed antibacterial activity, twelve of which exhibited activity against the multi‐drug resistant Escherichia coli 1699, implying that some of the bioactive compounds could be novel. Genome sequencing of two of these isolates confirmed that they harbour uncharacterized biosynthetic pathways that may encode novel chemical structures. View Full-Text
Keywords: Isodictya compressa; Higginsia bidentifera; natural products; marine sponge; antimicrobial Isodictya compressa; Higginsia bidentifera; natural products; marine sponge; antimicrobial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Matobole, R.M.; van Zyl, L.J.; Parker‐Nance, S.; Davies‐Coleman, M.T.; Trindade, M. Antibacterial Activities of Bacteria Isolated from the Marine Sponges Isodictya compressa and Higginsia bidentifera Collected from Algoa Bay, South Africa. Mar. Drugs 2017, 15, 47.

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