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Mar. Drugs 2017, 15(2), 24; doi:10.3390/md15020024

Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii

Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
College of Chemistry and Pharmacy, Qingdao Agricultural University, Changcheng Road 700, Qingdao 266109, China
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 11 September 2016 / Revised: 10 January 2017 / Accepted: 16 January 2017 / Published: 25 January 2017
(This article belongs to the Special Issue Marine Fungal Natural Products)
View Full-Text   |   Download PDF [1184 KB, uploaded 25 January 2017]   |  


Four new indolediketopiperazine derivatives (14), along with nine known congeners (513), were isolated and identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus obtained from the marine alga Sargassum thunbergii. The structures of thesecompounds were elucidated on the basis of extensive spectroscopic analysis and the absolute configurations of compounds 14 were established by NOESY experiments and by chiral HPLC analyses of their acid hydrolysates. The absolute configuration of C-8 (a quaternary carbon substituted with a hydroxyl group) in 5 of preechinulin class was firstly determined by electronic circular dichroism (ECD) calculations. All these compounds were evaluatedfor brine shrimp (Artemia salina) lethality and nematicidal activity as well as antioxidativeand antimicrobial potency. View Full-Text
Keywords: endophytic fungus; marine alga; Eurotium cristatum; indolediketopiperazine; bioactivity endophytic fungus; marine alga; Eurotium cristatum; indolediketopiperazine; bioactivity

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Du, F.-Y.; Li, X.; Li, X.-M.; Zhu, L.-W.; Wang, B.-G. Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii. Mar. Drugs 2017, 15, 24.

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