Cucumarioside A2-2 Causes Macrophage Activation in Mouse Spleen
AbstractThe immunomodulatory effect of triterpene glycoside cucumarioside A2-2 (CA2-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage activating markers iba-1, IL-1β, iNOs, ROS and NO formation, with additional change of macrophage phenotype to M1. The mass spectrometry profiles of peptide/protein were obtained using MALDI-TOF-MS on the different parts of spleen sections isolated by laser mircodissection techniques. It was found that i.p. stimulation of animals with CA2-2 leads to marked changes in the intensity of the characteristic peaks of spleen peptides/proteins, primarily in red pulp. View Full-Text
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Pislyagin, E.A.; Manzhulo, I.V.; Gorpenchenko, T.Y.; Dmitrenok, P.S.; Avilov, S.A.; Silchenko, A.S.; Wang, Y.-M.; Aminin, D.L. Cucumarioside A2-2 Causes Macrophage Activation in Mouse Spleen. Mar. Drugs 2017, 15, 341.
Pislyagin EA, Manzhulo IV, Gorpenchenko TY, Dmitrenok PS, Avilov SA, Silchenko AS, Wang Y-M, Aminin DL. Cucumarioside A2-2 Causes Macrophage Activation in Mouse Spleen. Marine Drugs. 2017; 15(11):341.Chicago/Turabian Style
Pislyagin, Evgeny A.; Manzhulo, Igor V.; Gorpenchenko, Tatiana Y.; Dmitrenok, Pavel S.; Avilov, Sergey A.; Silchenko, Alexandra S.; Wang, Yun-Ming; Aminin, Dmitry L. 2017. "Cucumarioside A2-2 Causes Macrophage Activation in Mouse Spleen." Mar. Drugs 15, no. 11: 341.
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