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Mar. Drugs 2017, 15(11), 339; doi:10.3390/md15110339

Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1

1
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
2
Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China
3
School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
4
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
5
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa 519020, Macau (SAR), China
*
Author to whom correspondence should be addressed.
Received: 30 August 2017 / Revised: 25 October 2017 / Accepted: 26 October 2017 / Published: 1 November 2017
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Abstract

By adding l-tryptophan and l-phenylalanine to GPY medium, twenty-eight compounds, including amides, polyketides, a sesquiterpenoid, a diterpenoid, a meroterpenoid, diketopiperazines, β-carbolines, fumiquinazolines, and indole alkaloids, were discovered from the marine-derived fungus Dichotomomyces cejpii F31-1, demonstrating the tremendous biosynthetic potential of this fungal strain. Among these compounds, four amides dichotomocejs A–D (14), one polyketide dichocetide A (5), and two diketopiperazines dichocerazines A–B (15 and 16) are new. The structures of these new compounds were determined by interpreting detailed spectroscopic data as well as calculating optical rotation values and ECD spectra. Obviously, Dichotomomyces cejpii can effectively use an amino acid-directed strategy to enhance the production of nitrogen-containing compounds. Dichotomocej A (1) displayed moderate cytotoxicity against the human rhabdomyosarcoma cell line RD with an IC50 value of 39.1 µM, and pityriacitrin (22) showed moderate cytotoxicity against the human colon carcinoma cell line HCT116 with an IC50 value of 35.1 µM. View Full-Text
Keywords: Dichotomomyces cejpii; diverse secondary metabolites; amino acid-directed strategy; nitrogen-containing compounds; bioactivity Dichotomomyces cejpii; diverse secondary metabolites; amino acid-directed strategy; nitrogen-containing compounds; bioactivity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chen, Y.-X.; Xu, M.-Y.; Li, H.-J.; Zeng, K.-J.; Ma, W.-Z.; Tian, G.-B.; Xu, J.; Yang, D.-P.; Lan, W.-J. Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1. Mar. Drugs 2017, 15, 339.

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