Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites
AbstractSince the discovery of penicillin, Penicillium has become one of the most attractive fungal genera for the production of bioactive molecules. Marine-derived Penicillium has provided numerous excellent pharmaceutical leads over the past decades. In this review, we focused on the cytotoxic metabolites * (* Cytotoxic potency was referred to five different levels in this review, extraordinary (IC50/LD50: <1 μM or 0.5 μg/mL); significant (IC50/LD50: 1~10 μM or 0.5~5 μg/mL); moderate (IC50/LD50: 10~30 μM or 5~15 μg/mL); mild (IC50/LD50: 30~50 μM or 15~25 μg/mL); weak (IC50/LD50: 50~100 μM or 25~50 μg/mL). The comparative potencies of positive controls were referred when they were available). produced by marine-derived Penicillium species, and on their cytotoxicity mechanisms, biosyntheses, and chemical syntheses. View Full-Text
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Liu, S.; Su, M.; Song, S.-J.; Jung, J.H. Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites. Mar. Drugs 2017, 15, 329.
Liu S, Su M, Song S-J, Jung JH. Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites. Marine Drugs. 2017; 15(10):329.Chicago/Turabian Style
Liu, Sen; Su, Mingzhi; Song, Shao-Jiang; Jung, Jee H. 2017. "Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites." Mar. Drugs 15, no. 10: 329.
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