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Mar. Drugs 2017, 15(1), 6; doi:10.3390/md15010006

Merosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Disease

1
Eskitis Institute for Drug Discovery, Griffith University, Brisbane 4111, Australia
2
School of Fundamental Science, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Malaysia
3
Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Malaysia
4
Queensland Museum, Brisbane 4101, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 23 September 2016 / Revised: 30 November 2016 / Accepted: 2 December 2016 / Published: 27 December 2016
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
View Full-Text   |   Download PDF [2348 KB, uploaded 27 December 2016]   |  

Abstract

A study of the chemical constituents from the Australian Sponge Hyrtios digitatus has provided a perspective on the connection between the chemistry and biology of the puupehenones, a unique and unusual class of merosesquiterpenes. In this study, a new tetracyclic merosesquiterpene, 19-methoxy-9,15-ene-puupehenol (1) was isolated from the marine sponge Hyrtios digitatus along with the known 20-methoxy-9,15-ene-puupehenol (2). Their structures were elucidated on the basis of spectroscopic data (1H and 13C NMR) in combination with experimental electronic circular dichroism (ECD) data. Compounds 1 and 2 are active at 1.78 μM and 3.05 μM, respectively, on Scavenger Receptor-Class B Type 1 HepG2 (SR-B1 HepG2) stable cell lines, targeting atherosclerosis disease. View Full-Text
Keywords: Hyrtios digitatus; merosesquiterpene; atherosclerosis; HepG2; SR-B1 Hyrtios digitatus; merosesquiterpene; atherosclerosis; HepG2; SR-B1
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Wahab, H.A.; Pham, N.B.; Muhammad, T.S.T.; Hooper, J.N.A.; Quinn, R.J. Merosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Disease. Mar. Drugs 2017, 15, 6.

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