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Mar. Drugs 2016, 14(8), 156; doi:10.3390/md14080156

An Unusual Conformational Isomer of Verrucosidin Backbone from a Hydrothermal Vent Fungus, Penicillium sp. Y-50-10

1
Ocean College, Zhejiang University, Hangzhou 310058, China
2
Department of Oceanography, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
3
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
*
Author to whom correspondence should be addressed.
Academic Editor: Russell Kerr
Received: 5 July 2016 / Revised: 10 August 2016 / Accepted: 15 August 2016 / Published: 18 August 2016
(This article belongs to the Special Issue Marine Fungal Natural Products)
View Full-Text   |   Download PDF [973 KB, uploaded 18 August 2016]   |  

Abstract

A new verrucosidin derivative, methyl isoverrucosidinol (1), was isolated from the marine fungus Penicillium sp. Y-50-10, dwelling in sulfur rich sediment in the Kueishantao hydrothermal vents off Taiwan. The structure was established by spectroscopic means including HRMS and 2D-NMR spectroscopic analysis. The absolute configuration was defined mainly by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Among hitherto known compounds with a verrucosidine backbone isolated from natural resource, compound 1 represents the first example of a new conformational isomer of its skeleton, exhibiting antibiotic activity against Bacillus subtilis with MIC value 32 μg/mL. View Full-Text
Keywords: marine fungus; Penicillium sp.; verrucosidin; conformational isomer; antibiotic marine fungus; Penicillium sp.; verrucosidin; conformational isomer; antibiotic
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MDPI and ACS Style

Pan, C.; Shi, Y.; Auckloo, B.N.; Chen, X.; Chen, C.-T.A.; Tao, X.; Wu, B. An Unusual Conformational Isomer of Verrucosidin Backbone from a Hydrothermal Vent Fungus, Penicillium sp. Y-50-10. Mar. Drugs 2016, 14, 156.

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