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Mar. Drugs 2016, 14(9), 157; doi:10.3390/md14090157

Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp.

1
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
2
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
3
Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China
4
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China
5
School of Life Sciences, Xiamen University, Xiamen 361102, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 1 July 2016 / Revised: 17 August 2016 / Accepted: 20 August 2016 / Published: 26 August 2016
(This article belongs to the Special Issue Marine Fungal Natural Products)
View Full-Text   |   Download PDF [1664 KB, uploaded 26 August 2016]   |  

Abstract

By the method of 1H NMR prescreening and tracing the diagnostic proton signals of the methyl groups, three additional new triquinane-type sesquiterpenoids—chondrosterins K–M (13) and the known sesquiterpenoid anhydroarthrosporone (4)—were isolated from the marine fungus Chondrostereum sp. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Chondrosterin K is a rare hirsutane sesquiterpenoid, in which a methyl group was migrated from C-2 to C-6 and has a double bond between C-2 and C-3. Compounds 13 showed significant cytotoxicities against various cancer cell lines in vitro. View Full-Text
Keywords: Chondrostereum sp.; chondrosterin; hirsutane; sesquiterpenoid; cytotoxicity Chondrostereum sp.; chondrosterin; hirsutane; sesquiterpenoid; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Huang, L.; Lan, W.-J.; Deng, R.; Feng, G.-K.; Xu, Q.-Y.; Hu, Z.-Y.; Zhu, X.-F.; Li, H.-J. Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp.. Mar. Drugs 2016, 14, 157.

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