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Mar. Drugs 2016, 14(8), 155; doi:10.3390/md14080155

Mirabolides A and B; New Cytotoxic Glycerides from the Red Sea Sponge Theonella mirabilis

1
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
2
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt
*
Author to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 15 May 2016 / Revised: 5 August 2016 / Accepted: 8 August 2016 / Published: 18 August 2016
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
View Full-Text   |   Download PDF [768 KB, uploaded 18 August 2016]   |  

Abstract

As a part of our continuing work to find out bioactive lead molecules from marine invertebrates, the CHCl3 fraction of the organic extract of the Red Sea sponge Theonella mirabilis showed cytotoxic activity in our primary screen. Bioassay-guided purification of the active fractions of the sponge’s extract resulted in the isolation of two new glycerides, mirabolides A and B (1 and 2), together with the reported 4-methylene sterols, conicasterol (3) and swinhosterol B (4). The structures of the compounds were assigned by interpretation of their 1D (1H, 13C), 2D (COSY, HSQC, HMBC, ROESY) NMR spectral data and high-resolution mass determinations. Compounds 14 displayed marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with IC50 values of 16.4, 5.18, 6.23 and 3.0 μg/mL, respectively, compared to 5.4 μg/mL observed by doxorubicin as reference drug. View Full-Text
Keywords: Red Sea sponge Theonella mirabilis; glycerides; Mirabolides A and B; 4-methylene sterols; breast cancer cell line; cytotoxic activity Red Sea sponge Theonella mirabilis; glycerides; Mirabolides A and B; 4-methylene sterols; breast cancer cell line; cytotoxic activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Abou-Hussein, D.R.; Youssef, D.T.A. Mirabolides A and B; New Cytotoxic Glycerides from the Red Sea Sponge Theonella mirabilis. Mar. Drugs 2016, 14, 155.

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