Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum
AbstractTen new cembrane-based diterpenes, locrassumins A–G (1–7), (–)-laevigatol B (8), (–)-isosarcophine (9), and (–)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11–18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8–24 μM. View Full-Text
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Zhao, M.; Cheng, S.; Yuan, W.; Xi, Y.; Li, X.; Dong, J.; Huang, K.; Gustafson, K.R.; Yan, P. Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum. Mar. Drugs 2016, 14, 111.
Zhao M, Cheng S, Yuan W, Xi Y, Li X, Dong J, Huang K, Gustafson KR, Yan P. Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum. Marine Drugs. 2016; 14(6):111.Chicago/Turabian Style
Zhao, Min; Cheng, Shimiao; Yuan, Weiping; Xi, Yiyuan; Li, Xiubao; Dong, Jianyong; Huang, Kexin; Gustafson, Kirk R.; Yan, Pengcheng. 2016. "Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum." Mar. Drugs 14, no. 6: 111.
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