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Mar. Drugs 2016, 14(5), 98; doi:10.3390/md14050098

Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the “Supply Problem”

1
REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal
2
Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA
3
Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles, Campus de la Plaine, CP205/1, Boulevard du Triomphe, 1050 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 29 March 2016 / Revised: 29 April 2016 / Accepted: 5 May 2016 / Published: 21 May 2016
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
View Full-Text   |   Download PDF [2899 KB, uploaded 21 May 2016]   |  

Abstract

Marine invertebrates provide a rich source of metabolites with anticancer activities and several marine-derived agents have been approved for the treatment of cancer. However, the limited supply of promising anticancer metabolites from their natural sources is a major hurdle to their preclinical and clinical development. Thus, the lack of a sustainable large-scale supply has been an important challenge facing chemists and biologists involved in marine-based drug discovery. In the current review we describe the main strategies aimed to overcome the supply problem. These include: marine invertebrate aquaculture, invertebrate and symbiont cell culture, culture-independent strategies, total chemical synthesis, semi-synthesis, and a number of hybrid strategies. We provide examples illustrating the application of these strategies for the supply of marine invertebrate-derived anticancer agents. Finally, we encourage the scientific community to develop scalable methods to obtain selected metabolites, which in the authors’ opinion should be pursued due to their most promising anticancer activities. View Full-Text
Keywords: eribulin; trabectedin; mycalamide A; spongistatin 1; stelletin A; monanchocidin A; phenylmethylene hydantoin; frondoside A; discodermolide eribulin; trabectedin; mycalamide A; spongistatin 1; stelletin A; monanchocidin A; phenylmethylene hydantoin; frondoside A; discodermolide
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gomes, N.G.M.; Dasari, R.; Chandra, S.; Kiss, R.; Kornienko, A. Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the “Supply Problem”. Mar. Drugs 2016, 14, 98.

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