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Mar. Drugs 2016, 14(5), 101; doi:10.3390/md14050101

Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids

1
Centro de Espectrometria de Massa, Departamento de Química & QOPNA, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal
2
Allmicroalgae—Natural Products S.A., Avenida das Forças Armadas, 125, 7º piso, 1600-079 Lisboa, Portugal
3
ALGAplus-Produção e Comercialização de Algas e Derivados, Lda., 3830-196 Ílhavo, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Andrew Desbois
Received: 19 February 2016 / Revised: 9 May 2016 / Accepted: 12 May 2016 / Published: 19 May 2016
(This article belongs to the Special Issue Marine Fatty Acids-2016)
View Full-Text   |   Download PDF [2236 KB, uploaded 19 May 2016]   |  

Abstract

In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated fatty acids (PUFAs) like n-3 α-linolenic (ALA 18:3), eicosapentaenoic (EPA, 20:5) and docosahexaenoic (DHA, 22:6). GLs comprise three major classes: monogalactosyldiacyl glycerolipids (MGDGs), digalactosyl diacylglycerolipids (DGDGs) and sulfoquinovosyl diacylglycerolipids (SQDGs), whose composition in FA directly depends on the growth conditions. Some of these lipids are high value-added compounds with antitumoral, antimicrobial and anti-inflammatory activities and also with important nutritional significance. To fully explore GLs’ bioactive properties it is necessary to fully characterize their structure and to understand the relation between the structure and their biological properties, which can be addressed using modern mass spectrometry (MS)-based lipidomic approaches. This review will focus on the up-to-date FA composition of GLs identified by MS-based lipidomics and their potential as phytochemicals. View Full-Text
Keywords: lipidomic; glycolipids; microalgae; fatty acids; mass spectrometry; bioprospection lipidomic; glycolipids; microalgae; fatty acids; mass spectrometry; bioprospection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

da Costa, E.; Silva, J.; Mendonça, S.H.; Abreu, M.H.; Domingues, M.R. Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids. Mar. Drugs 2016, 14, 101.

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