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Mar. Drugs 2016, 14(2), 30; doi:10.3390/md14020030

Yessotoxin, a Promising Therapeutic Tool

1
Department of Pharmacology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain
2
Department of Physiology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Received: 4 December 2015 / Revised: 15 January 2016 / Accepted: 18 January 2016 / Published: 28 January 2016
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Abstract

Yessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in filter feeding shellfish. No records about human intoxications induced by this compound have been published, however it is considered a toxin. Modifications in second messenger levels, protein levels, immune cells, cytoskeleton or activation of different cellular death types have been published as consequence of YTX exposure. This review summarizes the main intracellular pathways modulated by YTX and their pharmacological and therapeutic implications. View Full-Text
Keywords: yessotoxin (YTX); apoptosis; autophagy; cellular death; signal transduction; cytoskeleton; immune system; Alzheimer; glucose metabolism yessotoxin (YTX); apoptosis; autophagy; cellular death; signal transduction; cytoskeleton; immune system; Alzheimer; glucose metabolism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Alfonso, A.; Vieytes, M.R.; Botana, L.M. Yessotoxin, a Promising Therapeutic Tool. Mar. Drugs 2016, 14, 30.

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