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Mar. Drugs 2016, 14(10), 182; doi:10.3390/md14100182

Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats

1
Department of Plastic Surgery, the Second Affiliated Hospital, Soochow University, Suzhou 215004, China
2
Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou 215123, China
3
College of Pharmaceutical Science, Soochow University, Suzhou 215123, China
4
Department of Pathology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
5
Institute of Radiology & Oncology, Soochow University, Suzhou 215006, China
6
Suzhou Key Laboratory of Tumor Microenvironment Pathology, Suzhou 215123, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Hitoshi Sashiwa and David Harding
Received: 12 August 2016 / Revised: 30 August 2016 / Accepted: 31 August 2016 / Published: 11 October 2016
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan II, 2017)
View Full-Text   |   Download PDF [4293 KB, uploaded 11 October 2016]   |  

Abstract

Radiation-induced skin injury, which remains a serious concern in radiation therapy, is currently believed to be the result of vascular endothelial cell injury and apoptosis. Here, we established a model of acute radiation-induced skin injury and compared the effect of different vascular growth factors on skin healing by observing the changes of microcirculation and cell apoptosis. Vascular endothelial growth factor (VEGF) was more effective at inhibiting apoptosis and preventing injury progression than other factors. A new strategy for improving the bioavailability of vascular growth factors was developed by loading VEGF with chitosan nanoparticles. The VEGF-chitosan nanoparticles showed a protective effect on vascular endothelial cells, improved the local microcirculation, and delayed the development of radioactive skin damage. View Full-Text
Keywords: radiation-induced skin injury; VEGF; chitosan; nanoparticles; apoptosis radiation-induced skin injury; VEGF; chitosan; nanoparticles; apoptosis
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MDPI and ACS Style

Yu, D.; Li, S.; Wang, S.; Li, X.; Zhu, M.; Huang, S.; Sun, L.; Zhang, Y.; Liu, Y.; Wang, S. Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats. Mar. Drugs 2016, 14, 182.

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