Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites
AbstractThree new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4–11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1–3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1–11 were also examined to evaluate the anti-inflammatory potential, and 2–4 were shown to exhibit significant activities. View Full-Text
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Huang, C.-Y.; Chang, C.-W.; Tseng, Y.-J.; Lee, J.; Sung, P.-J.; Su, J.-H.; Hwang, T.-L.; Dai, C.-F.; Wang, H.-C.; Sheu, J.-H. Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites. Mar. Drugs 2016, 14, 180.
Huang C-Y, Chang C-W, Tseng Y-J, Lee J, Sung P-J, Su J-H, Hwang T-L, Dai C-F, Wang H-C, Sheu J-H. Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites. Marine Drugs. 2016; 14(10):180.Chicago/Turabian Style
Huang, Chiung-Yao; Chang, Che-Wei; Tseng, Yen-Ju; Lee, Jessica; Sung, Ping-Jyun; Su, Jui-Hsin; Hwang, Tsong-Long; Dai, Chang-Feng; Wang, Hui-Chun; Sheu, Jyh-Horng. 2016. "Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites." Mar. Drugs 14, no. 10: 180.
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