Next Article in Journal
New Metabolites and Bioactive Actinomycins from Marine-Derived Streptomyces sp. ZZ338
Previous Article in Journal
Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2016, 14(10), 180; doi:10.3390/md14100180

Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites

1
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
2
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
4
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
5
Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
6
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
7
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
8
College of Medicine and PhD Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
9
Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
11
Frontier Center for Ocean Science and Technology, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 31 August 2016 / Revised: 19 September 2016 / Accepted: 21 September 2016 / Published: 11 October 2016
View Full-Text   |   Download PDF [1500 KB, uploaded 11 October 2016]   |  

Abstract

Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (411), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 13 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 111 were also examined to evaluate the anti-inflammatory potential, and 24 were shown to exhibit significant activities. View Full-Text
Keywords: soft coral; Umbellulifera petasites; steroid; cytotoxic activity; anti-inflammatory activity soft coral; Umbellulifera petasites; steroid; cytotoxic activity; anti-inflammatory activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Huang, C.-Y.; Chang, C.-W.; Tseng, Y.-J.; Lee, J.; Sung, P.-J.; Su, J.-H.; Hwang, T.-L.; Dai, C.-F.; Wang, H.-C.; Sheu, J.-H. Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites. Mar. Drugs 2016, 14, 180.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top