Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages
AbstractMicrometam C is a core of novel marine compound isolated from the mangrove associates Micromelum falcatum. In this study, we investigated the protective effects of micrometam C in inflammation models in the transgenic zebrafish line Tg (corola: eGFP) and RAW264.7 macrophages. We found that micrometam C significantly suppressed the migration of immune cells in tail-cutting-induced inflammation in transgenic zebrafish and reduced lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) in both zebrafish and macrophages. In addition, micrometam C also restored LPS-induced reduction of endogenous antioxidants, such as catalase (CAT), glutathione (GSH) and superoxide dismutase (SOD). The protective effects of micrometam C were in parallel to its inhibition of NADPH oxidase and nuclear factor-kappa-binding (NF-κB) activity. Thus, the present results demonstrate that micrometam C protects against LPS-induced inflammation possibly through its antioxidant property. View Full-Text
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Tang, H.; Ge, H.; Chen, Z.-B.; Luo, X.-M.; Su, F.-J.; Liang, Y.-B.; Li, Z.-Y.; Wu, J.-G.; Yang, Q.; Zeng, L.-J.; Ma, Z.-F. Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages. Mar. Drugs 2015, 13, 5593-5605.
Tang H, Ge H, Chen Z-B, Luo X-M, Su F-J, Liang Y-B, Li Z-Y, Wu J-G, Yang Q, Zeng L-J, Ma Z-F. Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages. Marine Drugs. 2015; 13(9):5593-5605.Chicago/Turabian Style
Tang, Hao; Ge, Hui; Chen, Zhi-Bin; Luo, Xiong-Ming; Su, Feng-Juan; Liang, Yan-Bing; Li, Zhen-Yu; Wu, Jing-Guo; Yang, Qing; Zeng, Li-Jin; Ma, Zhong-Fu. 2015. "Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages." Mar. Drugs 13, no. 9: 5593-5605.