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Mar. Drugs 2015, 13(9), 5593-5605; doi:10.3390/md13095593

Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages

1
Department of General Internal Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
2
Department of Health Care Clinic, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
3
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
4
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Keith B. Glaser
Received: 29 May 2015 / Revised: 13 August 2015 / Accepted: 18 August 2015 / Published: 28 August 2015
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Abstract

Micrometam C is a core of novel marine compound isolated from the mangrove associates Micromelum falcatum. In this study, we investigated the protective effects of micrometam C in inflammation models in the transgenic zebrafish line Tg (corola: eGFP) and RAW264.7 macrophages. We found that micrometam C significantly suppressed the migration of immune cells in tail-cutting-induced inflammation in transgenic zebrafish and reduced lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) in both zebrafish and macrophages. In addition, micrometam C also restored LPS-induced reduction of endogenous antioxidants, such as catalase (CAT), glutathione (GSH) and superoxide dismutase (SOD). The protective effects of micrometam C were in parallel to its inhibition of NADPH oxidase and nuclear factor-kappa-binding (NF-κB) activity. Thus, the present results demonstrate that micrometam C protects against LPS-induced inflammation possibly through its antioxidant property. View Full-Text
Keywords: micrometam C; inflammatory; zebrafish; NF-κB; NADPH oxidase micrometam C; inflammatory; zebrafish; NF-κB; NADPH oxidase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tang, H.; Ge, H.; Chen, Z.-B.; Luo, X.-M.; Su, F.-J.; Liang, Y.-B.; Li, Z.-Y.; Wu, J.-G.; Yang, Q.; Zeng, L.-J.; Ma, Z.-F. Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages. Mar. Drugs 2015, 13, 5593-5605.

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