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Mar. Drugs 2015, 13(9), 5579-5592; doi:10.3390/md13095579

New Furan and Cyclopentenone Derivatives from the Sponge-Associated Fungus Hypocrea Koningii PF04

1
College of Pharmacy, Jinan University, Guangzhou 510632, China
2
Marine Drugs Research Center, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
3
State Key Laboratory of Microbial Metabolism, Marine Biotechnology Laboratory, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 19 June 2015 / Revised: 14 August 2015 / Accepted: 17 August 2015 / Published: 26 August 2015
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Abstract

Two new furan derivatives, hypofurans A and B (1 and 2), and three new cyclopentenone derivatives, hypocrenones A–C (35), along with seven known compounds (612), were isolated from a marine fungus Hypocrea koningii PF04 associated with the sponge Phakellia fusca. Among them, compounds 10 and 11 were obtained for the first time as natural products. The planar structures of compounds 15 were elucidated by analysis of their spectroscopic data. Meanwhile, the absolute configuration of 1 was determined as 2R,3R by the comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. All the isolates were evaluated for their antibacterial and antioxidant activity. Compounds 1, 10, and 12 all showed modest antibacterial activity against Staphylococcus aureus ATCC25923 (MIC, 32 μg/mL). In addition, compounds 1, 10 and 11 exhibited moderate DPPH radical scavenging capacity with IC50 values of 27.4, 16.8, and 61.7 µg/mL, respectively. View Full-Text
Keywords: Hypocrea koningii; sponge-associated fungus; furan derivatives; cyclopentenone derivatives; antibacterial; antioxidant Hypocrea koningii; sponge-associated fungus; furan derivatives; cyclopentenone derivatives; antibacterial; antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ding, L.-J.; Gu, B.-B.; Jiao, W.-H.; Yuan, W.; Li, Y.-X.; Tang, W.-Z.; Yu, H.-B.; Liao, X.-J.; Han, B.-N.; Li, Z.-Y.; Xu, S.-H.; Lin, H.-W. New Furan and Cyclopentenone Derivatives from the Sponge-Associated Fungus Hypocrea Koningii PF04. Mar. Drugs 2015, 13, 5579-5592.

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